Epidemiologic features and outcomes associated with caustic ingestion among adults admitted in intensive care unit from 2013 to 2019: a French national observational study

• Published in: European journal of trauma and emergency surgery (Munich : 2007) 2024-06, Vol.50 (3), p.905-912
• Main Authors: Deniau, Benjamin, Boulet, Nicolas, Pétrier, Melissa, Mezzarobba, Myriam, Coutrot, Maxime, Cattan, Pierre, Corté, Helene, Dépret, François, Lefrant, Jean-Yves, Plaud, Benoit, Boudemaghe, Thierry
• Format: Article
• Language: English
• Subjects: Adult; Aged; Burns, Chemical - epidemiology; Burns, Chemical - mortality; Caustic soda; Caustics - poisoning; Caustics - toxicity; Clinical outcomes; Critical Care Medicine; Emergency Medicine; Epidemiology; Female; France - epidemiology; Hospital Mortality; Humans; Intensive; Intensive care; Intensive Care Units; Length of Stay - statistics & numerical data; Male; Medicine; Medicine & Public Health; Middle Aged; Mortality; Original Article; Poisoning; Retrospective Studies; Sports Medicine; Surgery; Surgical Orthopedics; Traumatic Surgery
• ISSN: 1863-9933; 1863-9941; 1863-9941
• DOI: 10.1007/s00068-023-02392-9

Purpose Caustic ingestion is a potential life-threatening condition associated with high morbidity and mortality. Data on patients admitted to Intensive Care Unit (ICU) for severe caustic ingestion are lacking. We aimed to describing epidemiological features and outcomes of patients admitted to ICU for caustic ingestion in France. Methods In a retrospective, observational, and multicenter study, data from the national French Programme de Médicalisation des Systèmes d’Informations (PMSI) database were analysed from 2013 to 2019. In-hospital mortality rate (primary outcome) and in-ICU complications (secondary outcomes) were reported and analysed. Results 569 patients (289 males (50.8%), with median age of 49 years [interquartile (26–62)] were admitted in 65 French ICU for severe caustic ingestion. Five hundred and thirteen patients (90%) were admitted for intentional caustic ingestion. The median length of stay in ICU was 14.0 [4.0–31.0] days. In-hospital mortality occurred in 56 patients (9.8%). In multivariate analysis, age and simplified acute physiology score II were associated with in-hospital mortality age of 40–59 years [OR = 15.3 (2.0–115.3)], age of 60–79 years [OR = 23.6 (3.1–182.5)], and age > 80 years [OR = 37.0 (4.2–328.6)] and SAPS 2 score [OR = 1.0018 (1.003–1.033), p   40 years and SAPS 2 score were independently associated with mortality.