Could serum HMGB1 levels be a predictor associated with psoriatic arthritis?

Psoriasis is a chronic autoimmune disease that predominantly affects the skin and musculoskeletal system. We hypothesized that HMGB1, an inflammatory nuclear protein, may play a role in the musculoskeletal involvement of psoriasis. Forty patients with psoriasis and 45 with psoriatic arthritis were i...

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Bibliographic Details
Published in:Biomarkers in medicine 2023-10, Vol.17 (20), p.871-880
Main Authors: Yildirim, Derya, Baykul, Merve, Edek, Yusuf C, Gulengul, Mehmet, Alp, Gizem T, Eroglu, Fatma S, Adisen, Esra, Kucuk, Hamit, Erden, Abdulsamet, Goker, Berna, Nas, Kemal, Ozturk, Mehmet A
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic - diagnosis
Chronic Disease
enthesitis
HMGB1
HMGB1 Protein
Humans
PASI score
Psoriasis
psoriatic arthritis
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Summary:Psoriasis is a chronic autoimmune disease that predominantly affects the skin and musculoskeletal system. We hypothesized that HMGB1, an inflammatory nuclear protein, may play a role in the musculoskeletal involvement of psoriasis. Forty patients with psoriasis and 45 with psoriatic arthritis were involved in the study; the results were compared with 22 healthy controls. Serum HMGB1 levels were evaluated from peripheral blood samples. Serum HMGB1 levels were found to be significantly higher in patients with psoriasis regardless of joint involvement (p 
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2023-0490