H2O2-stimulated Janus-shaped self-propelled nanomotors as an active treatment for acute renal injury

As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with l-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Jan...

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Bibliographic Details
Published in:Nanoscale 2024-01, Vol.16 (3), p.1282-1290
Main Authors: Xu, Jun, Zhong, Yali, Wang, Weixin, Gao, Rui, Wang, Yini, Tong, Fei, Sun, Jiahui, Hong, Miaofang, Qiao, Lingyan, Qiao, Weiwei, Mei, Qibing, Wu, Jianming
Format: Article
Language:English
Subjects:
Asymmetry
Chitosan
Hydrogen peroxide
Injuries
Kidneys
Melatonin
Nanomaterials
Nanotechnology devices
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Summary:As emerging nanosystems, nanomotors have been applied in the active treatment of many diseases. In this paper, Pt@chitosan-loaded melatonin asymmetrical nanomaterials embedded with l-serine (S, kidney injury molecule 1-targeting agent) were constructed to alleviate acute kidney injury (AKI). The Janus nanocarriers arrived at the renal injury site via the bloodstream and exhibited high permeability. Because of melatonin distribution in the kidneys combined with H2O2-stimulated O2 release, the administration of the Janus nanosystem resulted in active treatment through the motion of nanomotors by asymmetrical O2 release.
ISSN:2040-3364
2040-3372
DOI:10.1039/d3nr04808j