Human-specific translational control of neuronal mitochondria and excitability

How are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al. reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protectiv...

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Published in:Neuron (Cambridge, Mass.) Mass.), 2023-12, Vol.111 (24), p.3901-3903
Main Authors: Lane, Alicia R, Wynne, Meghan E, Faundez, Victor
Format: Article
Language:English
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Summary:How are human-specific brain bioenergetics and excitability connected? In this Neuron issue, Shen et al. reveal a human-specific interaction between RACK1 mRNA and FMRP. Reducing RACK1 mimics FMRP-dependent excitability and mitochondrial phenotypes, which can be reversed with mitochondrial-protective drugs. These findings suggest that FMRP-mediated translation adapts mitochondria to excitability energy demands.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2023.10.031