Tongue electrical impedance myography correlates with functional, neurophysiologic, and clinical outcome measures in long‐term oropharyngeal cancer survivors with and without hypoglossal neuropathy: An exploratory study

Background This pilot study analyzed correlations between tongue electrical impedance myography (EIM), standard tongue electromyography (EMG), and tongue functional measures in N = 4 long‐term oropharyngeal cancer (OPC) survivors. Methods Patients were screened for a supportive care trial (NCT041510...

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Bibliographic Details
Published in:Head & neck 2024-03, Vol.46 (3), p.581-591
Main Authors: Hansen, Nathan J., Woodman, Karin, Buoy, Sheila, Mao, Shitong, Barbon, Carly E. A., Lai, Stephen Y., Fuller, C. David, Hutcheson, Katherine A., Sanchez, Benjamin
Format: Article
Language:English
Subjects:
Cranial nerves
Electric Impedance
Electrical impedance
electrical impedance myography
Electromyography
Head & neck cancer
head and neck cancer
Humans
Hypoglossal nerve
Hypoglossal Nerve Diseases
Isometric
lower cranial neuropathy
Muscle, Skeletal
Myography
Neuropathy
Oropharyngeal cancer
Oropharyngeal Neoplasms - therapy
Outcome Assessment, Health Care
Pilot Projects
radiotherapy
Reinnervation
Survivors
Throat cancer
Tongue
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Summary:Background This pilot study analyzed correlations between tongue electrical impedance myography (EIM), standard tongue electromyography (EMG), and tongue functional measures in N = 4 long‐term oropharyngeal cancer (OPC) survivors. Methods Patients were screened for a supportive care trial (NCT04151082). Hypoglossal nerve function was evaluated with genioglossus needle EMG, functional measures with the Iowa oral performance instrument (IOPI), and multi‐frequency tissue composition with tongue EIM. Results Tongue EIM conductivity was higher for patients with EMG‐confirmed cranial nerve XII neuropathy than those without (p = 0.005) and in patients with mild versus normal EMG reinnervation ratings (16 kHz EIM: p = 0.051). Tongue EIM correlated with IOPI strength measurements (e.g., anterior maximum isometric lingual strength: r2 = 0.62, p = 0.020). Conclusions Tongue EIM measures related to tongue strength and the presence of XII neuropathy. Noninvasive tongue EIM may be a convenient adjunctive biomarker to assess tongue health in OPC survivors.
ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.27618