Survival outcomes and prognostic factors of infratentorial glioblastoma in the elderly

Infratentorial glioblastoma(itGBM) is a rare and rapidly progressive form of GBM with poor prognosis. However, no studies have adequately examined itGBM outcomes in elderly patients (>65 years). Here, we used a national database to fill this knowledge gap. SEER 18 registries were utilized to iden...

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2024-01, Vol.236, p.108084-108084, Article 108084
Main Authors: Chandra, Ankush, Lopez-Rivera, Victor, Ryba, Bryan, Chandran, Arjun S., Brandel, Michael G., Dono, Antonio, Sheinberg, Dallas L., Esquenazi, Yoshua L., Aghi, Manish K.
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Aged
Aged, 80 and over
Brain cancer
Brain Neoplasms - drug therapy
Brain Neoplasms - therapy
Brain stem
Cancer therapies
Cerebellum
Chemotherapy
Elderly
Ethnicity
Female
Glioblastoma
Glioblastoma - pathology
Humans
Infratentorial
Infratentorial Neoplasms
Kaplan-Meier Estimate
Male
Marital status
Medical prognosis
Multivariate analysis
Older people
Patients
Prognosis
Proportional Hazards Models
Radiation
Radiation therapy
Regression analysis
Sociodemographics
Statistical analysis
Survival
Treatment Outcome
Tumors
Citations: Items that this one cites
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Summary:Infratentorial glioblastoma(itGBM) is a rare and rapidly progressive form of GBM with poor prognosis. However, no studies have adequately examined itGBM outcomes in elderly patients (>65 years). Here, we used a national database to fill this knowledge gap. SEER 18 registries were utilized to identify adult itGBM patients diagnosed between 2000–2016. itGBM cases were further divided into cerebellar and brainstem GBM as cGBM and bGBM, respectively. Kaplan–Meier analysis and Cox hazards proportional regression models were performed to assess factors associated with overall survival (OS). Among 137 (33%) elderly patients from the study cohort (N = 420), median age was 74 years, 38% were female, and 85% were white. Median OS in elderly itGBM patients was shorter than younger adults (10 vs. 5-months, p 
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2023.108084