Ampullary Adenocarcinoma: A Review of the Mutational Landscape and Implications for Treatment

Ampullary carcinomas represent less than 1% of all gastrointestinal malignancies with an incidence of approximately 6 cases per 1 million. Histologic examination and immunohistochemistry have been traditionally used to categorize ampullary tumors into intestinal, pancreatobiliary or mixed subtypes....

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Bibliographic Details
Published in:Cancers 2023-12, Vol.15 (24), p.5772
Main Authors: Tsagkalidis, Vasileios, Langan, Russell C, Ecker, Brett L
Format: Article
Language:English
Subjects:
Adenocarcinoma
Antimitotic agents
Antineoplastic agents
Bile ducts
Biomarkers
Cancer
Cancer therapies
Care and treatment
Classification
Gastrointestinal system
Gastrointestinal tract
Genes
Genetic aspects
Genomics
Histology
Immunohistochemistry
Intestine
Malignancy
Medical prognosis
Oncology
Pancreatic cancer
Pancreaticoduodenectomy
Precision medicine
Stains & staining
Surveillance
Tumors
Citations: Items that this one cites
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Description
Summary:Ampullary carcinomas represent less than 1% of all gastrointestinal malignancies with an incidence of approximately 6 cases per 1 million. Histologic examination and immunohistochemistry have been traditionally used to categorize ampullary tumors into intestinal, pancreatobiliary or mixed subtypes. Intestinal-subtype tumors may exhibit improved survival versus the pancreatobiliary subtype, although studies on the prognostic value of immunomorphologic classification have been inconsistent. Genomic classifiers hold the promise of greater reliability, while providing potential targets for precision oncology. Multi-institutional collaboration will be necessary to better understand how molecular classification can guide type and sequencing of multimodality therapy.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15245772