Automated electrochemiluminescence immunoassay for serum PlGF levels in women with singleton pregnancy at 9-13 weeks of gestation predicts preterm preeclampsia: a retrospective cohort study

• Published in: Hypertension research 2024-05, Vol.47 (5), p.1196-1207
• Main Authors: Ohkuchi, Akihide, Takahashi, Kayo, Hirashima, Chikako, Suzuki, Hirotada, Takahashi, Hironori, Nagayama, Shiho, Ogoyama, Manabu, Horie, Kenji, Usui, Rie, Fujiwara, Hiroyuki
• Format: Article
• Language: English
• ISSN: 0916-9636; 1348-4214
• DOI: 10.1038/s41440-023-01534-1

Our aims were to obtain the gestational-age-specific median of common logarithmic placental growth factor (PlGF) values in the first trimester in women with a singleton pregnancy in order to generate the gestational-age-specific multiple of the median (MoM) of log PlGF at 9-13 weeks of gestation, to evaluate screening parameters of MoM of log PlGF at 9-13 weeks of gestation to predict preterm preeclampsia (PE), and to construct an appropriate prediction model for preterm PE using minimum risk factors in multivariable logistic regression analyses in a retrospective sub-cohort study. Preterm PE occurred in 2.9% (20/700), and PE in 5.1% (36/700). Serum PlGF levels were measured using Elecsys PlGF . MoMs of log PlGF at 9-13 weeks of gestation in Japanese women with a singleton pregnancy followed a normal distribution. We determined the appropriate cut-off value of MoM of log PlGF to predict preterm PE at around a10% false-positive rate (0.854). The MoM of log PlGF