The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multipl...

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Bibliographic Details
Published in:Cancers 2023-12, Vol.15 (24), p.5747
Main Authors: Milković, Lidija, Mlinarić, Monika, Lučić, Ivan, Čipak Gašparović, Ana
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Antioxidants
Aquaporins
Breast cancer
Cancer
Cancer therapies
Chemotherapy
Detoxification
Development and progression
DNA binding proteins
Drug resistance in microorganisms
Enzymes
Forkhead protein
Glycerol
Health aspects
Hydrogen peroxide
Immunotherapy
Metastases
Metastasis
Multidrug resistance
Oxidative stress
Phenotypes
Prevention
Radiation therapy
Signal transduction
Transcription factors
Tumors
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Summary:Breast cancer is still the leading cause of death in women of all ages. The reason for this is therapy resistance, which leads to the progression of the disease and the formation of metastases. Multidrug resistance (MDR) is a multifactorial process that leads to therapy failure. MDR involves multiple processes and many signaling pathways that support each other, making it difficult to overcome once established. Here, we discuss cellular-oxidative-stress-modulating factors focusing on transcription factors NRF2, FOXO family, and peroxiporins, as well as their possible contribution to MDR. This is significant because oxidative stress is a consequence of radiotherapy, chemotherapy, and immunotherapy, and the activation of detoxification pathways could modulate the cellular response to therapy and could support MDR. These proteins are not directly responsible for MDR, but they support the survival of cancer cells under stress conditions.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15245747