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Heterogeneous parathyroid near‐infrared autofluorescence patterns are associated with single adenomas in primary hyperparathyroidism
Background Primary adenoma (PA) and multi‐gland hyperplasia (MGH) account for 85% and 15% of primary hyperparathyroidism (PHPT) cases, respectively. Near‐infrared autofluorescence (NIRAF) enhances intraoperative parathyroid identification. We hypothesized that PA would display a more heterogeneous N...
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Published in: | Head & neck 2024-03, Vol.46 (3), p.592-598 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Primary adenoma (PA) and multi‐gland hyperplasia (MGH) account for 85% and 15% of primary hyperparathyroidism (PHPT) cases, respectively. Near‐infrared autofluorescence (NIRAF) enhances intraoperative parathyroid identification. We hypothesized that PA would display a more heterogeneous NIRAF pattern compared to MGH.
Methods
Patients undergoing surgery for sporadic PHPT were categorized based on the presence of PA or MGH. To quantify heterogeneity, we utilized ratios of (1) mean parathyroid gland (PG) NIRAF over background NIRAF (mean ratio), (2) minimum and (3) maximum PG NIRAF over mean PG NIRAF (minimum and maximum ratios). Additionally, a heterogeneity score was quantified using mean ratio (mean PG NIRAF over background NIRAF), and overall NIRAF (mean NIRAF of eight random 15 × 15 pixel areas). A point was assigned to ratios 1.2. Images were quantified by ImageJ software. Mann–Whitney test was performed for all comparisons.
Results
Of 78 patients, 63 had a single PA and 15 had MGH, totaling 102 PGs. There was no difference between their mean ratios. PA had a lower minimum ratio compared to that of MGH (0.86 ± 0.01 vs. 0.93 ± 0.01, p = 0.001) and a brighter maximum ratio (1.21 ± 0.02 vs. 1.12 ± 0.01, p = 0.0008). PA also scored higher on their heterogeneity scores compared to MGH (1.27 ± 0.23 vs. 0.33 ± 0.15, p = 0.001).
Conclusion
Single parathyroid adenomas display a more heterogeneous autofluorescence pattern compared to that of multi‐gland hyperplasia. Intraoperative characterization of PGs by real‐time NIR imaging patterns may be a beneficial adjunct during parathyroid surgery. |
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ISSN: | 1043-3074 1097-0347 1097-0347 |
DOI: | 10.1002/hed.27599 |