Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease

Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, and eosinophilic CRS (eCRS) is a subtype characterized by significant eosinophil infiltration and immune response by T-helper-2 cells. The pathogenesis of eCRS is heterogeneous and involves various environmental...

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Published in:International journal of molecular sciences 2023-12, Vol.24 (24), p.17372
Main Authors: Kim, Jaehyeong, Kwak, Sooun, Lee, Juhyun, Park, Il-Ho, Lee, Seung Hoon, Shin, Jae Min, Kim, Tae Hoon
Format: Article
Language:English
Subjects:
Allergens
Biological products
Chronic Disease
Classification
Disease
Endopeptidases
Enzymes
Eosinophils
Humans
Hypersensitivity - pathology
Inflammation
Medical imaging
Medical research
Nose
Pathogenesis
Peptide Hydrolases
Pollutants
Polyps
Protease Inhibitors
Rhinitis - pathology
Rhinosinusitis
Sinuses
Sinusitis - pathology
Steroids
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container_title International journal of molecular sciences
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creator Kim, Jaehyeong
Kwak, Sooun
Lee, Juhyun
Park, Il-Ho
Lee, Seung Hoon
Shin, Jae Min
Kim, Tae Hoon
description Chronic rhinosinusitis (CRS) is an inflammation of the nasal and paranasal sinus mucosa, and eosinophilic CRS (eCRS) is a subtype characterized by significant eosinophil infiltration and immune response by T-helper-2 cells. The pathogenesis of eCRS is heterogeneous and involves various environmental and host factors. Proteases from external sources, such as mites, fungi, and bacteria, have been implicated in inducing type 2 inflammatory reactions. The balance between these proteases and endogenous protease inhibitors (EPIs) is considered important, and their imbalance can potentially lead to type 2 inflammatory reactions, such as eCRS. In this review, we discuss various mechanisms by which exogenous proteases influence eCRS and highlight the emerging role of endogenous protease inhibitors in eCRS pathogenesis.
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subjects Allergens
Biological products
Chronic Disease
Classification
Disease
Endopeptidases
Enzymes
Eosinophils
Humans
Hypersensitivity - pathology
Inflammation
Medical imaging
Medical research
Nose
Pathogenesis
Peptide Hydrolases
Pollutants
Polyps
Protease Inhibitors
Rhinitis - pathology
Rhinosinusitis
Sinuses
Sinusitis - pathology
Steroids
title Eosinophilic Chronic Rhinosinusitis and Pathogenic Role of Protease
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