Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants

Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteo...

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Bibliographic Details
Published in:Materials 2023-12, Vol.16 (24), p.7524
Main Authors: Sharipova, Aliya, Zlotver, Ivan, Sosnik, Alejandro, Rabkin, Eugen
Format: Article
Language:English
Subjects:
Alloys
Annealing
Antibiotics
Biomedical materials
Conjugation
Drying
Gold
High resolution
Interfacial bonding
Ion beams
Microscopy
Nanoparticles
Orthopaedic implants
Orthopedics
Photoelectrons
Polyethylene glycol
Reagents
Reproducibility
Scanning electron microscopy
Scanning transmission electron microscopy
Solid state
Spectrum analysis
Substrates
Surgical implants
Temperature
Thin films
Titanium base alloys
Transplants & implants
Vancomycin
X ray photoelectron spectroscopy
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Summary:Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteoinductive agents. In this framework, Au nanoparticles are produced on the surface of Ti-6Al-4V medical alloy by solid-state dewetting of 5 nm Au film and used as the substrate for the conjugation of a model antibiotic vancomycin via a mono-thiolated poly(ethylene glycol) linker. Produced Au nanoparticles on Ti-6Al-4V surface are equiaxed with a mean diameter 19.8 ± 7.2 nm, which is shown by high-resolution scanning electron microscopy and atomic force microscopy. The conjugation of the antibiotic vancomycin, 18.8 ± 1.3 nm-thick film, is confirmed by high resolution-scanning transmission electron microscopy and X-ray photoelectron spectroscopy. Overall, showing a link between the solid-state dewetting process and surface functionalization, we demonstrate a novel, simple, and versatile method for functionalization of implant surfaces.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma16247524