Effects of High-Intensity Interval Training Using the 3/7 Resistance Training Method on Metabolic Stress in People with Heart Failure and Coronary Artery Disease: A Randomized Cross-Over Study

• Published in: Journal of clinical medicine 2023-12, Vol.12 (24), p.7743
• Main Authors: Gillet, Alexis, Forton, Kevin, Lamotte, Michel, Macera, Francesca, Roussoulières, Ana, Louis, Pauline, Ibrahim, Malko, Dewachter, Céline, van de Borne, Philippe, Deboeck, Gaël
• Format: Article
• Language: English
• Subjects: Anaerobic threshold; Biosynthesis; Blood pressure; Cardiovascular disease; Care and treatment; Coronary heart disease; Coronary vessels; Ejection fraction; Ethylenediaminetetraacetic acid; Exercise; Exercise therapy; Health aspects; Heart; Heart failure; Heart rate; Hemodynamics; Hormones; Insulin; Insulin-like growth factors; Interval training; Kinases; Metabolism; Metabolites; Methods; Muscle strength; Musculoskeletal system; Physical fitness; Rehabilitation; Rest; Somatotropin; Strength training; Stress (Physiology); Testing; Vein & artery diseases; Weight training
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12247743

The 3/7 resistance training (RT) method involves performing sets with increasing numbers of repetitions, and shorter rest periods than the 3x9 method. Therefore, it could induce more metabolic stress in people with heart failure with reduced ejection fraction (HFrEF) or coronary artery disease (CAD). This randomized cross-over study tested this hypothesis. Eleven individuals with HFrEF and thirteen with CAD performed high-intensity interval training (HIIT) for 30 min, followed by 3x9 or 3/7 RT according to group allocation. pH, HCO , lactate, and growth hormone were measured at baseline, after HIIT, and after RT. pH and HCO decreased, and lactate increased after both RT methods. In the CAD group, lactate increased more (6.99 ± 2.37 vs. 9.20 ± 3.57 mmol/L, = 0.025), pH tended to decrease more (7.29 ± 0.06 vs. 7.33 ± 0.04, = 0.060), and HCO decreased more (18.6 ± 3.1 vs. 21.1 ± 2.5 mmol/L, = 0.004) after 3/7 than 3x9 RT. In the HFrEF group, lactate, pH, and HCO concentrations did not differ between RT methods (all > 0.248). RT did not increase growth hormone in either patient group. In conclusion, the 3/7 RT method induced more metabolic stress than the 3x9 method in people with CAD but not HFrEF.