Inflammation in Heart Failure-Future Perspectives

Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes affecting around 1-2% of the global population and more than 10% of the people above the age of 65. Inflammation is persistently associated with chronic diseases, contributing in many cases to the progress...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-12, Vol.12 (24), p.7738
Main Authors: Arvunescu, Alexandru Mircea, Ionescu, Ruxandra Florentina, Cretoiu, Sanda Maria, Dumitrescu, Silviu Ionel, Zaharia, Ondin, Nanea, Ioan Tiberiu
Format: Article
Language:English
Subjects:
Biomarkers
Cardiomyocytes
Chronic diseases
Chronic illnesses
Clinical medicine
Cytokines
Development and progression
Diabetes
Diagnosis
Disease
Ejection fraction
Genotype & phenotype
Heart failure
Immune system
Inflammation
Medical research
Medicine, Experimental
Mitochondrial DNA
Mortality
Nitric oxide
Risk factors
Type 2 diabetes
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Summary:Chronic heart failure is a terminal point of a vast majority of cardiac or extracardiac causes affecting around 1-2% of the global population and more than 10% of the people above the age of 65. Inflammation is persistently associated with chronic diseases, contributing in many cases to the progression of disease. Even in a low inflammatory state, past studies raised the question of whether inflammation is a constant condition, or if it is, rather, triggered in different amounts, according to the phenotype of heart failure. By evaluating the results of clinical studies which focused on proinflammatory cytokines, this review aims to identify the ones that are independent risk factors for heart failure decompensation or cardiovascular death. This review assessed the current evidence concerning the inflammatory activation cascade, but also future possible targets for inflammatory response modulation, which can further impact the course of heart failure.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12247738