The Anti-Inflammatory Effect of Multi-Wavelength Light-Emitting Diode Irradiation Attenuates Dry Eye Symptoms in a Scopolamine-Induced Mouse Model of Dry Eye

Dry eye disease is a common condition in patients of all ages, causing discomfort and potential visual problems. Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic pote...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-12, Vol.24 (24), p.17493
Main Authors: Goo, Hyeyoon, Lee, Yea-Jin, Lee, Sangkeun, Hong, Namgue
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - adverse effects
Cornea
Cornea - pathology
Corneal Injuries - pathology
Cytokines
Disease Models, Animal
Dry Eye Syndromes - chemically induced
Dry Eye Syndromes - drug therapy
Dry Eye Syndromes - pathology
Humans
Inflammation
Light emitting diodes
Light therapy
Medical research
Mice
Scopolamine - adverse effects
Tears
Toxicity
Wound healing
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Summary:Dry eye disease is a common condition in patients of all ages, causing discomfort and potential visual problems. Current treatments, including artificial tears and anti-inflammatory drugs, have certain limitations, encouraging research into alternative therapies. We investigated the therapeutic potential of multi-wavelength light-emitting diode (LED) irradiation of mice with dry eye. First, we showed that multi-wavelength LED irradiation was non-toxic to human corneal epithelial cells and improved cell viability. We then used a scopolamine-induced mouse model of dry eye to assess the effects of multi-wavelength LED irradiation on various clinical parameters. This treatment increased the tear volume and reduced corneal irregularity, thus improving dry eye. Histological analysis revealed that multi-wavelength LED irradiation protected against corneal epithelial damage and the associated reduction in epithelial thickness and would thus improve the corneal health of dry eye patients. Multi-wavelength LED irradiation significantly reduced the corneal levels of pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; the treatment was thus anti-inflammatory. Our results suggest that multi-wavelength LED irradiation may serve as a safe and effective treatment for dry eye, alleviating symptoms, reducing inflammation, and promoting corneal health.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242417493