Achieving pre-eminence of antimicrobial resistance among non-fermenting Gram-negative bacilli causing septicemia in intensive care units: A single center study of a tertiary care hospital

Bloodstream infections in the intensive care unit have always been a global healthcare challenge. The present study was conducted with the aim to evaluate the yearly trend of antibiotic resistance in non-fermenting Gram-negative bacilli (NFGNB) causing septicemia in intensive care units. Blood sampl...

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Bibliographic Details
Published in:Germs (Bucureşti) 2023-06, Vol.13 (2), p.108-120
Main Authors: Kumar, Harit, Kaur, Narinder, Kumar, Nitin, Chauhan, Jyoti, Bala, Rosy, Chauhan, Shubham
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics
Antimicrobial agents
Care and treatment
Ciprofloxacin
Complications and side effects
Drug resistance
Drug resistance in microorganisms
Gynecology
Health aspects
Hospitals
Infectious diseases
Intensive care
Levofloxacin
Multidrug resistant organisms
Neurosurgery
Obstetrics
Patient outcomes
Pediatrics
Quality control
Sample size
Sepsis
Septicemia
Surgery
Tetracycline
Tetracyclines
Ticarcillin
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Summary:Bloodstream infections in the intensive care unit have always been a global healthcare challenge. The present study was conducted with the aim to evaluate the yearly trend of antibiotic resistance in non-fermenting Gram-negative bacilli (NFGNB) causing septicemia in intensive care units. Blood samples were collected from the patients admitted in various intensive care units and processed for isolation and identification of non-fermenting Gram-negative bacilli. The isolated bacterial strains were subjected to antibiotic susceptibility testing as per standard operating procedures. Out of 3632 blood samples, 977 (26.9%) samples showed microbial growth, of which 10.1% were Gram positive cocci, 8.7% were Gram negative bacilli (Enterobacterales), 7% were NFGNB and 1% were spp. Increasing resistance among complex was observed to ceftazidime, cefepime, amikacin, ciprofloxacin, levofloxacin, meropenem and trimethoprim-sulfamethoxazole. Moreover, strains were found to be associated with increased resistance to ciprofloxacin, levofloxacin, ceftazidime and meropenem. A substantial increase in resistance levels was observed among and as well. An increasing trend of antimicrobial resistance in NFGNB envisages the worst consequences in ICUs in the coming years. Therefore, reviewing and strict implementation of the antimicrobial policies including 'rational use of antibiotics' is recommended.
ISSN:2248-2997
2248-2997
DOI:10.18683/germs.2023.1374