Functional MRI evaluation of blood oxygen dependent (BOLD) in renal allograft dysfunction: a prospective study

Background Blood oxygen level dependent-magnetic resonance imaging (BOLD-MRI) is a non-invasive functional imaging technique that can be used to assess renal allograft dysfunction. Purpose To evaluate the diagnostic performance of BOLD-MRI using a 3-T scanner in discriminating causes of renal allogr...

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Published in:Acta radiologica (1987) 2024-05, Vol.65 (5), p.397-405
Main Authors: Farg, Hashim Mohamed, El-Diasty, Tarek, Ali-El-Dein, Bedeir, Refaie, Ayman, Abou El-Ghar, Mohamed
Format: Article
Language:English
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Summary:Background Blood oxygen level dependent-magnetic resonance imaging (BOLD-MRI) is a non-invasive functional imaging technique that can be used to assess renal allograft dysfunction. Purpose To evaluate the diagnostic performance of BOLD-MRI using a 3-T scanner in discriminating causes of renal allograft dysfunction in the post-transplant period. Material and Methods This prospective study was conducted on 112 live donor-renal allograft recipients: 53 with normal graft function, as controls; 18 with biopsy-proven acute rejection (AR); and 41 with biopsy-proven acute tubular necrosis (ATN). Multiple fast-field echo sequences were performed to obtain T2*-weighted images. Cortical R2* (CR2*) level, medullary R2* (MR2*) level, and medullary over cortical R2* ratio (MCR) were measured in all participants. Results The mean MR2* level was significantly lower in the AR group (20.8 ± 2.8/s) compared to the normal group (24 ± 2.4/s, P
ISSN:0284-1851
1600-0455
DOI:10.1177/02841851231217052