Intestinal Trefoil Factor 3: a new biological factor mediating gut-kidney crosstalk in diabetic kidney disease

• Published in: Endocrine 2024-04, Vol.84 (1), p.109-118
• Main Authors: Zhang, Tao, Zhang, Yinghui, Tao, Jie, Rong, Xianglu, Yang, Yiqi
• Format: Article
• Language: English
• Subjects: Animal models; Colon; Diabetes; Diabetes mellitus; Digestive system; Endocrinology; Extracellular matrix; Gastrointestinal tract; Glucose; Glucose tolerance; High fat diet; Humanities and Social Sciences; Internal Medicine; Kidney diseases; Medicine; Medicine & Public Health; Microenvironments; multidisciplinary; Original Article; Renal cortex; Science; Streptozocin; Trefoil factor
• ISSN: 1559-0100; 1355-008X; 1559-0100
• DOI: 10.1007/s12020-023-03559-5

Purpose To investigate the effect of TFF3 in the pathogenesis of Diabetic Kidney Disease (DKD), and explore the dynamic changes of TFF3 expression pattern in renal injury process. Methods DKD animal model was established by streptozotocin (STZ) (40 mg/kg/d, ip, for 5 days, consecutively) combined with the high fat diet (HFD) for 12 weeks. While animals were sacrificed at different time stages in DKD process (4 weeks, 8 weeks and 12 weeks, respectively). Results STZ combined with high-fat diet induced weight gain, increased blood glucose and decreased glucose tolerance in DKD mice. Compared to the control group, the DKD group exhibits extracellular matrix (ECM) accumulation and the renal injury was aggravated in a time-dependent manner. The TFF3 expression level was decreased in kidney, and increased in colon tissue. Conclusion TFF3 is not only expressed in colon, but also expressed in renal medulla and cortex. TFF3 might be play a pivotal role in renal mucosal repair by gut-kidney crosstalk, and protect renal from high glucose microenvironment damage.