Recent Progress in Ferroptosis Induced Tumor Cell Death by Anti‐tumor Metallic complexes

• Published in: Chemistry, an Asian journal an Asian journal, 2024-02, Vol.19 (3), p.e202301020-n/a
• Main Authors: Zhou, Yong‐Chang, Zhao, Tian‐Kun, Tao, Si‐Man, Wang, Peng, Guan, Yi‐Chen, Yang, Ke‐Pei, Chen, Sheng‐Qiang, Pu, Xiu‐Ying
• Format: Article
• Language: English
• Subjects: Cell Death; Coordination Complexes - pharmacology; Coordination compounds; Ferroptosis; Humans; Metal complexes; Neoplasms - drug therapy; Platinum; Tumor; Tumor immune; Tumors
• ISSN: 1861-4728; 1861-471X
• DOI: 10.1002/asia.202301020

Metal complexes represented by platinum complexes play a very important role in cancer treatment due to their diverse chemical structures and anti‐tumor activities. Recently, ferroptosis has emerged as a newly occurring cell death form in the anti‐tumor process. It has been reported that metal complexes could inhibit the proliferation and metastasis of tumors and combat chemotherapy resistance by targeting ferroptosis. In this review, we briefly describe ferroptosis as a fundamental process for tumor suppression and triggering anti‐tumor immune responses. We summarize recent developments on metal complexes that induce ferroptosis. Finally, we outline the prospects for the application of metal complexes to the treatment of tumors based on ferroptosis and the associated problems that need to be solved, and discussed other potential research directions of metal complexes. Ferroptosis has been a highlight in bioinorganic chemistry in recent years. Focusing on recent developments on metal complexes that induce ferroptosis, this review summarizes the research progress and prospects for the application of various metal complexes in the treatment of tumors based on ferroptosis together with the associated problems that need to be addressed. Future potential research areas of metal complexes with ferroptosis inducing ability are also proposed and discussed.