Mechanistic insights into the survival curve of HeLa cells with a short shoulder and their S phase-specific sensitivity

Abstract HeLa cells are a cell line with two unique cellular features: a short-shouldered survival curve and two peaks of radioresistance during the cell cycle phase, while their underlying mechanisms remain unclear. We herein proposed that these radiobiological features are due to a common mechanis...

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Bibliographic Details
Published in:Journal of radiation research 2024-03, Vol.65 (2), p.256-258
Main Authors: Komatsu, Kenshi, Tauchi, Hiroshi
Format: Article
Language:English
Subjects:
Cell Cycle
Cell Survival
DNA Repair
HeLa Cells
Humans
Radiation
Radiation Tolerance
S Phase
Shoulder
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Summary:Abstract HeLa cells are a cell line with two unique cellular features: a short-shouldered survival curve and two peaks of radioresistance during the cell cycle phase, while their underlying mechanisms remain unclear. We herein proposed that these radiobiological features are due to a common mechanism by which radiation suppresses homologous recombination repair (HRR) in a dose-dependent manner. This radio-suppression of HRR is mediated by an intra-S checkpoint and reduces survivals of cells in S phase, especially early S phase, resulting in both short shoulder and radioresistance with two peaks in the cell cycle. This new explanation may not be limited to HeLa cells since a similar close association of these features is also observed in other type of cells.
ISSN:0449-3060
1349-9157
DOI:10.1093/jrr/rrad097