Association between galectin-3 and the prognosis of patients with stroke: A meta-analysis of observational studies

This meta-analysis aimed to investigate the prognostic value of galectin-3 among patients with stroke. Electronic databases, such as PubMed, Web of Science, Embase, Cochrane, and Clinical Trials, were utilized for conducting searches from database inception to November 2022. Two reviewers independen...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-02, Vol.34 (2), p.270-280
Main Authors: Zhang, Xiaofeng, Yang, Linjia, Zhang, Jie, Huang, Pengpeng, Jin, Zhenhua, Liu, Yong, Zeng, Duchun
Format: Article
Language:English
Subjects:
confidence interval
Databases, Factual
Functional recovery
Galectin 3
galectins
Humans
meta-analysis
metabolism
Mortality
nutrition
odds ratio
Prognosis
risk
Stroke
Stroke - diagnosis
Stroke - therapy
Survivors
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Summary:This meta-analysis aimed to investigate the prognostic value of galectin-3 among patients with stroke. Electronic databases, such as PubMed, Web of Science, Embase, Cochrane, and Clinical Trials, were utilized for conducting searches from database inception to November 2022. Two reviewers independently screened the papers, extracted the data, and used the Newcastle-Ottawa Scale to determine the risk of bias. Stata 17 was employed to conduct the meta-analysis, while the funnel plot was utilized to identify potential publication bias. Subgroup and meta-regression analyses were employed to examine the sources of heterogeneity. Nine studies that satisfied the inclusion criteria were included. Galectin-3 levels were higher post-stroke in patients with poor outcomes and mortality compared to those in patients with good outcomes (standardized mean difference [SMD], 2.83; 95 % confidence interval [CI], 1.25–4.40; P
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2023.10.014