Simultaneous occurrence of multiple myeloma and acute myeloid leukemia: Case report and literature review

Multiple myeloma (MM) and acute myeloid leukemia (AML) are malignant clonal diseases of cells in different lineages. It remains very rare to have both diseases at first diagnosis. Only 24 cases of this situation were reported from 1971 to 2021, and poor prognosis in most cases. However, here we desc...

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Bibliographic Details
Published in:Cancer genetics 2024-04, Vol.282-283, p.9-13
Main Authors: Li, Feng, Yang, Feifei, Zhang, Xiuqun, Cao, Shibin, Xu, Yanli
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Multiple myeloma
Treatment
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Summary:Multiple myeloma (MM) and acute myeloid leukemia (AML) are malignant clonal diseases of cells in different lineages. It remains very rare to have both diseases at first diagnosis. Only 24 cases of this situation were reported from 1971 to 2021, and poor prognosis in most cases. However, here we describe a case of de novo MM and AML occurring simultaneously in a 65-year-old woman. We have successfully used individualized treatment regimens to allow the patient to survive 1.5 years to date, which has exceeded 80 % of statistical cases.
ISSN:2210-7762
2210-7770
DOI:10.1016/j.cancergen.2023.12.005