The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion

• Published in: Journal of drug targeting 2024-02, Vol.32 (2), p.1-185
• Main Authors: de Oliveira, Daysiane, Luiz, Gabriel Paulino, Scussel, Rahisa, Fagundes, Mirian Ivens, Galvani, Nathália Coral, Abel, Jessica da Silva, Zaccaron, Rubya Pereira, de Bem Silveira, Gustavo, de Andrade, Thiago Antônio Moretti, Lock Silveira, Paulo Cesar, Andrez Machado-de-Ávila, Ricardo
• Format: Article
• Language: English
• ISSN: 1061-186X; 1029-2330
• DOI: 10.1080/1061186X.2023.2298848

The search for fast and efficient treatment for dermonecrotic lesions caused by the venom of the spider from the , is a demand in health. Prednisolone is one of the most used drugs, however it has side effects. In this context, addictionally gold nanoparticles (GNPs) have anti-inflammatory, antioxidant, and antibacterial properties. The use of photobiomodulation has show to be efficient in the process of tissue repair. Therefore, the purpose of this study was to investigate the anti-inflammatory effect of photobiomodulation and GNPs associated or not with a low concentration of prednisolone in animal models of dermonecrotic lesion. For this, rabbits with venon-induced dermonecrotic lesion were subjected to topical treatment with prednisolone + laser or GNPs + laser or Pred-GNPs + laser. The area of edema, necrosis and erythema were measured. On the last day of treatment, the animals were euthanized to remove the organs for histopathological and biochemical analysis. All treatments combinations were effective in promoting the reduction of necrotic tissue and erythema. With this results, we suggest that the use of laser and nanoparticles, associated or not with prednisolone, should be considered for the treatment of dermonecrotic injury.