A recombinant signalling‐selective activated protein C that lacks anticoagulant activity is efficacious and safe in cutaneous wound preclinical models

Various preclinical and clinical studies have demonstrated the robust wound healing capacity of the natural anticoagulant activated protein C (APC). A bioengineered APC variant designated 3K3A‐APC retains APC's cytoprotective cell signalling actions with

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Bibliographic Details
Published in:Wound repair and regeneration 2024-01, Vol.32 (1), p.90-103
Main Authors: Zhao, Ruilong, Xue, Meilang, Lin, Haiyan, Smith, Margaret, Liang, Helena, Weiler, Hartmut, Griffin, John H., Jackson, Christopher J.
Format: Article
Language:English
Subjects:
3K3A‐APC
activated protein C (APC)
animal model
cell culture
wound healing
Citations: Items that this one cites
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Description
Summary:Various preclinical and clinical studies have demonstrated the robust wound healing capacity of the natural anticoagulant activated protein C (APC). A bioengineered APC variant designated 3K3A‐APC retains APC's cytoprotective cell signalling actions with
ISSN:1067-1927
1524-475X
1524-475X
DOI:10.1111/wrr.13148