Systematic Review and Meta-Analysis on Piroplasma spp. Infection and Co-infection with Anaplasma marginale in Domestic Ruminants from Algeria

• Published in: Acta parasitologica 2024-03, Vol.69 (1), p.135-151
• Main Authors: Nahal, Amir, Ben Said, Mourad
• Format: Article
• Language: English
• Subjects: Algeria - epidemiology; Anaplasma marginale; Anaplasma marginale - genetics; Anaplasma marginale - isolation & purification; Anaplasmosis; Anaplasmosis - epidemiology; Animal diseases; Animal health; Animal Systematics/Taxonomy/Biogeography; Animals; Babesia; Babesia - genetics; Babesia - isolation & purification; Babesiosis - epidemiology; Babesiosis - parasitology; Biomedical and Life Sciences; Biomedicine; Cattle; Cattle Diseases - epidemiology; Cattle Diseases - microbiology; Cattle Diseases - parasitology; Coinfection - epidemiology; Coinfection - microbiology; Coinfection - parasitology; Coinfection - veterinary; Domestic animals; Ecology; Goat Diseases - epidemiology; Goat Diseases - microbiology; Goat Diseases - parasitology; Goats; Impact analysis; Infections; Infectious diseases; Livestock; Medical Microbiology; Meta-analysis; Microbiology; Parasitology; Piroplasma; Prevalence; Review; Sheep; Sheep Diseases - epidemiology; Sheep Diseases - parasitology; Theileria; Theileria - classification; Theileria - genetics; Theileria - isolation & purification; Theileriasis - epidemiology; Theileriasis - parasitology; Vector-borne diseases
• ISSN: 1230-2821; 1896-1851; 1896-1851
• DOI: 10.1007/s11686-023-00768-w

Background Piroplasmosis and anaplasmosis stand out as the primary diseases affecting livestock during periods of tick activity. These vector-borne diseases continue to emerge worldwide, exerting a detrimental impact on both animal health and national economies. The purpose of this study is to assess the prevalence of Piroplasma spp. and its co-occurrence with Anaplasma marginale in domestic ruminants in Algeria. Methods Three databases were systematically reviewed to identify eligible studies for the final meta-analysis, following the PRISMA statement. The 'meta' package in the R software was employed for the meta-analysis with the random effects model chosen for data pooling. Results The meta-analysis encompasses 14 research papers spanning a 19-year period (2004–2023). Theileria spp. was identified in all studies, covering 1675 cattle, 190 sheep, and 128 goats, yielding an overall Theileria infection rate of 45% (95% CI 26–65%). Specifically, cattle had a 59% infection rate, while sheep and goats had rates of 18% and 20%, respectively. Babesia spp. was found in nine studies, involving 1183 cattle and 190 sheep, resulting in an overall Babesia infection rate of 7% (95% CI 4–15%), with cattle and sheep having rates of 10% and 3%, respectively. Notably, eight Piroplasma species T. annulata , T. orientalis , T. buffeli , T. equi , Theileria sp., B. bovis , B. bigemina , and B. occultans were detected in cattle, with T. annulata being the most prevalent at 54%. Regional disparities and host factors also impacted infection rates, with higher rates in Northeastern Algeria and among suspected disease cattle. Additionally, gender, age, and breed influenced cattle susceptibility to Theileria infection. Furthermore, six distinct co-infections between Piroplasma spp. and A. marginale were observed, with T. annulata / A. marginale identified in six studies, demonstrating an 8.3% co-infection rate. Conclusion This analysis offers crucial insights into the current status of Piroplasmosis and its co-infection with A. marginale in Algerian domestic ruminants, providing valuable data for surveillance and prevention strategies.