Non-coding RNAs: Emerging biomarkers and therapeutic targets in ulcerative colitis

Ulcerative colitis (UC) is a persistent inflammatory condition affecting the colon's mucosal lining, leading to chronic bowel inflammation. Despite extensive research, the precise molecular mechanisms underlying UC pathogenesis remain elusive. NcRNAs form a category of functional RNA molecules...

Full description

Saved in:
Bibliographic Details
Published in:Pathology, research and practice research and practice, 2024-01, Vol.253, p.155037-155037, Article 155037
Main Authors: Kazmi, Imran, Altamimi, Abdulmalik Saleh Alfawaz, Afzal, Muhammad, Majami, Abdullah A., Abbasi, Fahad Al, Almalki, Waleed Hassan, Alzera, Sami I., Kukreti, Neelima, Fuloria, Neeraj Kumar, Fuloria, Shivkanya, Sekar, Mahendran, Abida
Format: Article
Language:English
Subjects:
CircRNAs
Diagnosis
LncRNAs
NcRNAs
Ulcerative colitis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ulcerative colitis (UC) is a persistent inflammatory condition affecting the colon's mucosal lining, leading to chronic bowel inflammation. Despite extensive research, the precise molecular mechanisms underlying UC pathogenesis remain elusive. NcRNAs form a category of functional RNA molecules devoid of protein-coding capacity. They have recently surfaced as pivotal modulators of gene expression and integral participants in various pathological processes, particularly those related to inflammatory disorders. The diverse classes of ncRNAs, encompassing miRNAs, circRNAs, and lncRNAs, have been implicated in UC. It highlights their involvement in key UC-related processes, such as immune cell activation, epithelial barrier integrity, and the production of pro-inflammatory mediators. ncRNAs have been identified as potential biomarkers for UC diagnosis and monitoring disease progression, offering promising avenues for personalized medicine. This approach may pave the way for novel, more specific treatments with reduced side effects, addressing the current limitations of conventional therapies. A comprehensive understanding of the interplay between ncRNAs and UC will advance our knowledge of the disease, potentially leading to more effective and personalized treatments for patients suffering from this debilitating condition. This review explores the pivotal role of ncRNAs in the context of UC, shedding light on their possible targets for diagnosis, prognosis, and therapeutic interventions.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.155037