Biomechanical and histomorphometric study on the bone–screw interface of bioactive ceramic-coated titanium screws

• Published in: Biomaterials 2005-06, Vol.26 (16), p.3249-3257
• Main Authors: Hyup Lee, Jae, Ryu, Hyun-Seung, Lee, Dong-Soo, Sun Hong, Kug, Chang, Bong-Soon, Lee, Choon-Ki
• Format: Article
• Language: English
• Subjects: Animals; Bioactive ceramic; Biocompatible Materials - chemistry; Biomechanical; Biomechanical Phenomena - methods; Bone Screws; Calcium Pyrophosphate - chemistry; Ceramics - chemistry; Coated Materials, Biocompatible - chemistry; Coating; Dogs; Histomorphometric analysis; Internal Fixators; Materials Testing; Osseointegration; Prostheses and Implants; Stress, Mechanical; Surface Properties; Tensile Strength; Tibia - pathology; Time Factors; Titanium - chemistry; Titanium screw
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2004.08.033

The purpose of this study was to compare the osseointegration of 4 different kinds of bioactive ceramic-coated screws with uncoated screws by biomechanical and histomorphometric analysis. Calcium pyrophosphate (CPP), apatite-wollastonite 1:3 glass ceramic (W3G), apatite-wollastonite 1:1 glass ceramic (WAG) and bioactive CaO–SiO 2–B 2O 3 glass ceramic (CSG) coatings were prepared and coated by the dipping method. Coated and uncoated titanium screws were inserted into the tibia of 18 adult mongrel male dogs for 2, 4, and 8 weeks. The insertion torques, radiographs, undecalcified histology, histomorphometric analysis, and extraction torques were evaluated. No difference of insertion torque was found among the five screw types. At 2 and 4 weeks after implantation, the extraction torque of ceramic-coated screws was significantly higher than that of uncoated screws ( p⩽0.0001). At 8 weeks, the extraction torques of CPP-, W3G-, and WAG-coated screws were significantly higher than those of CSG-coated and uncoated screws ( p