Indolent B-cell lymphoma with t(14;19) investigated from a molecular perspective

T(14;19) is an unusual but distinct genomic alteration reported in low-grade B-cell lymphomas. This structural rearrangement places BCL3 in juxtaposition with IGH inducing proliferation and has been found in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), marginal zone lymphoma (M...

Full description

Saved in:
Bibliographic Details
Published in:Journal of hematopathology 2023-12, Vol.16 (4), p.217-221
Main Authors: Karrs, Jeremiah X., Sathyanarayana, Shivaprasad H., Xu, Xinjie, Green, Donald C., Kahn, Wahab A., Loo, Eric Y., Kaur, Prabhjot
Format: Article
Language:English
Subjects:
Case Report
Hematology
Medicine
Medicine & Public Health
Pathology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:T(14;19) is an unusual but distinct genomic alteration reported in low-grade B-cell lymphomas. This structural rearrangement places BCL3 in juxtaposition with IGH inducing proliferation and has been found in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), marginal zone lymphoma (MZL), and other low-grade B-cell lymphomas. While there are some case series describing this in the context of other cytogenetic alterations, there are limited clinical cases examined from a molecular perspective. We herein describe a case of a low-grade B-cell lymphoma with t(14;19) resulting in IGH::BCL3 fusion on which we performed whole exome sequencing to investigate genetic variants that could contribute to its pathogenesis. We found pathogenic alterations including a variant in CXCR4 which has been shown to be recurrently mutated in different low-grade B-cell lymphomas including lymphoplasmacytic lymphoma (LPL) and MZL. We describe this interesting case in the context of its genomic findings and how it contributes to the literature as a whole.
ISSN:1868-9256
1865-5785
DOI:10.1007/s12308-023-00562-7