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Presentation of hypoparathyroidism in Italy: a nationwide register-based study
Purpose We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy. Methods We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of card...
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| Published in: | Journal of endocrinological investigation 2024, Vol.47 (8), p.2021-2027 |
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| Main Authors: | , , , , , |
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| container_end_page | 2027 |
| container_issue | 8 |
| container_start_page | 2021 |
| container_title | Journal of endocrinological investigation |
| container_volume | 47 |
| creator | Cipriani, C. Pepe, J. Colangelo, L. Cilli, M. Nieddu, L. Minisola, S. |
| description | Purpose
We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy.
Methods
We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of cardiovascular disease, cancer, infection, renal failure, psychiatric disease, upper airway tract infection and pneumonia, seizures, nephrolithiasis, cognitive impairment, cerebral calcifications, skin disorders, fracture, and cataract were retrieved when associated with the diagnosis of HypoPT (252.1). We excluded codes corresponding to diagnoses of cancer of the neck region. In-hospital mortality rate was calculated. We retrieved the same data from an age- and sex-matched non-HypoPT control population.
Results
Fourteen thousand five hundred seventy-nine hospitalizations for HypoPT and controls were analyzed. Hospitalization for cardiovascular disease, cancer, infection, renal failure, seizures, nephrolithiasis, cerebral calcifications (
p
|
| doi_str_mv | 10.1007/s40618-023-02271-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2910196867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3083927456</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-b3e8aa44771c0fae0e09b656d2f5eab40e0d252ca76427d6bc08876e2dd341dc3</originalsourceid><addsrcrecordid>eNp9kMlOwzAQhi0EoqXwAhxQJC5cAl4S2-GGKpZKFXCAs-XEkzZVNuxEKG-PacoiDhyssTXf_GN9CJ0SfEkwFlcuwpzIEFPmDxUkjPfQlAiKQ8kk3_91n6Aj5zYYM8GkOEQTJomIGcdT9PhswUHd6a5o6qDJg_XQNq22ulsPtilM4aqgqINFp8vhOtBBvQXfCwOBhVXhOrBhqh2YwHW9GY7RQa5LBye7OkOvd7cv84dw-XS_mN8sw4xR3oUpA6l1FAlBMpxrwICTlMfc0DwGnUb-bWhMMy14RIXhaYalFByoMSwiJmMzdDHmtrZ568F1qipcBmWpa2h6p2hCMEm45MKj53_QTdPb2v9OMSxZQkUUc0_Rkcps45yFXLW2qLQdFMHq07YabStvW21tq9gPne2i-7QC8z3ypdcDbAScb9UrsD-7_4n9AFgriqk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3083927456</pqid></control><display><type>article</type><title>Presentation of hypoparathyroidism in Italy: a nationwide register-based study</title><source>Springer Nature</source><creator>Cipriani, C. ; Pepe, J. ; Colangelo, L. ; Cilli, M. ; Nieddu, L. ; Minisola, S.</creator><creatorcontrib>Cipriani, C. ; Pepe, J. ; Colangelo, L. ; Cilli, M. ; Nieddu, L. ; Minisola, S.</creatorcontrib><description>Purpose
We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy.
Methods
We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of cardiovascular disease, cancer, infection, renal failure, psychiatric disease, upper airway tract infection and pneumonia, seizures, nephrolithiasis, cognitive impairment, cerebral calcifications, skin disorders, fracture, and cataract were retrieved when associated with the diagnosis of HypoPT (252.1). We excluded codes corresponding to diagnoses of cancer of the neck region. In-hospital mortality rate was calculated. We retrieved the same data from an age- and sex-matched non-HypoPT control population.
Results
Fourteen thousand five hundred seventy-nine hospitalizations for HypoPT and controls were analyzed. Hospitalization for cardiovascular disease, cancer, infection, renal failure, seizures, nephrolithiasis, cerebral calcifications (
p
< 0.0001), and cognitive impairment (
p
< 0.05) were more common in HypoPT compared to controls. Mean age of HypoPT with cardiovascular disease, cancer, and renal failure was younger compared to controls (
p
< 0.0001). The OR of hospitalization for cardiovascular disease, cancer, renal failure, seizures (OR 2, 40, 48 and 1.6, respectively), and nephrolithiasis (OR 1.6) were significant in HypoPT compared to non-HypoPT. The OR of hospitalization for infection and cognitive impairment were significant only in HypoPT women (OR 1.3 and 2.3, respectively). In-hospital mortality rate was lower in HypoPT vs controls (0.5% and 3.7%;
p
< 0.0001).
Conclusion
Hospitalizations for cardiovascular disease, cancer, and renal failure are more prevalent and occur at a younger age in HypoPT vs non-HypoPT. Hospitalizations for seizures and nephrolithiasis are frequent in HypoPT; those for infection and cognitive impairment are more common in HypoPT women.</description><identifier>ISSN: 1720-8386</identifier><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/s40618-023-02271-5</identifier><identifier>PMID: 38175360</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular system ; Cognitive ability ; Diagnosis ; Endocrinology ; Hospitalization ; Hypoparathyroidism ; Infections ; Internal Medicine ; Kidney diseases ; Kidney stones ; Medicine ; Medicine & Public Health ; Mental disorders ; Metabolic Diseases ; Mortality ; Nephrolithiasis ; Original Article ; Renal failure ; Respiratory tract diseases ; Seizures ; Skin diseases</subject><ispartof>Journal of endocrinological investigation, 2024, Vol.47 (8), p.2021-2027</ispartof><rights>The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE) 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-b3e8aa44771c0fae0e09b656d2f5eab40e0d252ca76427d6bc08876e2dd341dc3</cites><orcidid>0000-0001-5174-3347 ; 0000-0002-3088-0673 ; 0000-0002-7767-6776 ; 0000-0002-0141-1202 ; 0000-0001-6525-0439 ; 0000-0002-5835-9310</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38175360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cipriani, C.</creatorcontrib><creatorcontrib>Pepe, J.</creatorcontrib><creatorcontrib>Colangelo, L.</creatorcontrib><creatorcontrib>Cilli, M.</creatorcontrib><creatorcontrib>Nieddu, L.</creatorcontrib><creatorcontrib>Minisola, S.</creatorcontrib><title>Presentation of hypoparathyroidism in Italy: a nationwide register-based study</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Purpose
We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy.
Methods
We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of cardiovascular disease, cancer, infection, renal failure, psychiatric disease, upper airway tract infection and pneumonia, seizures, nephrolithiasis, cognitive impairment, cerebral calcifications, skin disorders, fracture, and cataract were retrieved when associated with the diagnosis of HypoPT (252.1). We excluded codes corresponding to diagnoses of cancer of the neck region. In-hospital mortality rate was calculated. We retrieved the same data from an age- and sex-matched non-HypoPT control population.
Results
Fourteen thousand five hundred seventy-nine hospitalizations for HypoPT and controls were analyzed. Hospitalization for cardiovascular disease, cancer, infection, renal failure, seizures, nephrolithiasis, cerebral calcifications (
p
< 0.0001), and cognitive impairment (
p
< 0.05) were more common in HypoPT compared to controls. Mean age of HypoPT with cardiovascular disease, cancer, and renal failure was younger compared to controls (
p
< 0.0001). The OR of hospitalization for cardiovascular disease, cancer, renal failure, seizures (OR 2, 40, 48 and 1.6, respectively), and nephrolithiasis (OR 1.6) were significant in HypoPT compared to non-HypoPT. The OR of hospitalization for infection and cognitive impairment were significant only in HypoPT women (OR 1.3 and 2.3, respectively). In-hospital mortality rate was lower in HypoPT vs controls (0.5% and 3.7%;
p
< 0.0001).
Conclusion
Hospitalizations for cardiovascular disease, cancer, and renal failure are more prevalent and occur at a younger age in HypoPT vs non-HypoPT. Hospitalizations for seizures and nephrolithiasis are frequent in HypoPT; those for infection and cognitive impairment are more common in HypoPT women.</description><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular system</subject><subject>Cognitive ability</subject><subject>Diagnosis</subject><subject>Endocrinology</subject><subject>Hospitalization</subject><subject>Hypoparathyroidism</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Kidney stones</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Metabolic Diseases</subject><subject>Mortality</subject><subject>Nephrolithiasis</subject><subject>Original Article</subject><subject>Renal failure</subject><subject>Respiratory tract diseases</subject><subject>Seizures</subject><subject>Skin diseases</subject><issn>1720-8386</issn><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kMlOwzAQhi0EoqXwAhxQJC5cAl4S2-GGKpZKFXCAs-XEkzZVNuxEKG-PacoiDhyssTXf_GN9CJ0SfEkwFlcuwpzIEFPmDxUkjPfQlAiKQ8kk3_91n6Aj5zYYM8GkOEQTJomIGcdT9PhswUHd6a5o6qDJg_XQNq22ulsPtilM4aqgqINFp8vhOtBBvQXfCwOBhVXhOrBhqh2YwHW9GY7RQa5LBye7OkOvd7cv84dw-XS_mN8sw4xR3oUpA6l1FAlBMpxrwICTlMfc0DwGnUb-bWhMMy14RIXhaYalFByoMSwiJmMzdDHmtrZ568F1qipcBmWpa2h6p2hCMEm45MKj53_QTdPb2v9OMSxZQkUUc0_Rkcps45yFXLW2qLQdFMHq07YabStvW21tq9gPne2i-7QC8z3ypdcDbAScb9UrsD-7_4n9AFgriqk</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Cipriani, C.</creator><creator>Pepe, J.</creator><creator>Colangelo, L.</creator><creator>Cilli, M.</creator><creator>Nieddu, L.</creator><creator>Minisola, S.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5174-3347</orcidid><orcidid>https://orcid.org/0000-0002-3088-0673</orcidid><orcidid>https://orcid.org/0000-0002-7767-6776</orcidid><orcidid>https://orcid.org/0000-0002-0141-1202</orcidid><orcidid>https://orcid.org/0000-0001-6525-0439</orcidid><orcidid>https://orcid.org/0000-0002-5835-9310</orcidid></search><sort><creationdate>2024</creationdate><title>Presentation of hypoparathyroidism in Italy: a nationwide register-based study</title><author>Cipriani, C. ; Pepe, J. ; Colangelo, L. ; Cilli, M. ; Nieddu, L. ; Minisola, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-b3e8aa44771c0fae0e09b656d2f5eab40e0d252ca76427d6bc08876e2dd341dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular system</topic><topic>Cognitive ability</topic><topic>Diagnosis</topic><topic>Endocrinology</topic><topic>Hospitalization</topic><topic>Hypoparathyroidism</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Kidney diseases</topic><topic>Kidney stones</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Metabolic Diseases</topic><topic>Mortality</topic><topic>Nephrolithiasis</topic><topic>Original Article</topic><topic>Renal failure</topic><topic>Respiratory tract diseases</topic><topic>Seizures</topic><topic>Skin diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cipriani, C.</creatorcontrib><creatorcontrib>Pepe, J.</creatorcontrib><creatorcontrib>Colangelo, L.</creatorcontrib><creatorcontrib>Cilli, M.</creatorcontrib><creatorcontrib>Nieddu, L.</creatorcontrib><creatorcontrib>Minisola, S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cipriani, C.</au><au>Pepe, J.</au><au>Colangelo, L.</au><au>Cilli, M.</au><au>Nieddu, L.</au><au>Minisola, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presentation of hypoparathyroidism in Italy: a nationwide register-based study</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2024</date><risdate>2024</risdate><volume>47</volume><issue>8</issue><spage>2021</spage><epage>2027</epage><pages>2021-2027</pages><issn>1720-8386</issn><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Purpose
We sought to assess the clinical presentation of hypoparathyroidism (HypoPT) in Italy.
Methods
We performed a nationwide study retrieving data from the hospital discharge ICD-9 codes database of the Italian Health Ministry, from 2007 through 2017. The codes corresponding to diagnosis of cardiovascular disease, cancer, infection, renal failure, psychiatric disease, upper airway tract infection and pneumonia, seizures, nephrolithiasis, cognitive impairment, cerebral calcifications, skin disorders, fracture, and cataract were retrieved when associated with the diagnosis of HypoPT (252.1). We excluded codes corresponding to diagnoses of cancer of the neck region. In-hospital mortality rate was calculated. We retrieved the same data from an age- and sex-matched non-HypoPT control population.
Results
Fourteen thousand five hundred seventy-nine hospitalizations for HypoPT and controls were analyzed. Hospitalization for cardiovascular disease, cancer, infection, renal failure, seizures, nephrolithiasis, cerebral calcifications (
p
< 0.0001), and cognitive impairment (
p
< 0.05) were more common in HypoPT compared to controls. Mean age of HypoPT with cardiovascular disease, cancer, and renal failure was younger compared to controls (
p
< 0.0001). The OR of hospitalization for cardiovascular disease, cancer, renal failure, seizures (OR 2, 40, 48 and 1.6, respectively), and nephrolithiasis (OR 1.6) were significant in HypoPT compared to non-HypoPT. The OR of hospitalization for infection and cognitive impairment were significant only in HypoPT women (OR 1.3 and 2.3, respectively). In-hospital mortality rate was lower in HypoPT vs controls (0.5% and 3.7%;
p
< 0.0001).
Conclusion
Hospitalizations for cardiovascular disease, cancer, and renal failure are more prevalent and occur at a younger age in HypoPT vs non-HypoPT. Hospitalizations for seizures and nephrolithiasis are frequent in HypoPT; those for infection and cognitive impairment are more common in HypoPT women.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38175360</pmid><doi>10.1007/s40618-023-02271-5</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5174-3347</orcidid><orcidid>https://orcid.org/0000-0002-3088-0673</orcidid><orcidid>https://orcid.org/0000-0002-7767-6776</orcidid><orcidid>https://orcid.org/0000-0002-0141-1202</orcidid><orcidid>https://orcid.org/0000-0001-6525-0439</orcidid><orcidid>https://orcid.org/0000-0002-5835-9310</orcidid></addata></record> |
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| subjects | Cancer Cardiovascular disease Cardiovascular diseases Cardiovascular system Cognitive ability Diagnosis Endocrinology Hospitalization Hypoparathyroidism Infections Internal Medicine Kidney diseases Kidney stones Medicine Medicine & Public Health Mental disorders Metabolic Diseases Mortality Nephrolithiasis Original Article Renal failure Respiratory tract diseases Seizures Skin diseases |
| title | Presentation of hypoparathyroidism in Italy: a nationwide register-based study |
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