The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids

Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship. Using an isogenic organoid platform to model pancreatic cance...

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Bibliographic Details
Published in:Cell stem cell 2024-01, Vol.31 (1), p.1-2
Main Authors: Bose, Shree, Shen, Xiling
Format: Article
Language:English
Subjects:
Humans
Lipid Metabolism
Metabolic Reprogramming
Organoids
Pancreatic Neoplasms
Proto-Oncogene Proteins p21(ras) - genetics
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Summary:Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship. Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2023.12.010