Magnetically controlled nanorobots induced oriented and rapid clearance of the cytokine storm for acute lung injury therapy

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2024-02, Vol.234, p.113731-113731, Article 113731
• Main Authors: Chen, Sheng, Chen, Enen, Guan, Xiaoling, Li, Junfang, Qin, Aiping, Wang, Chen, Fu, Xihua, Huang, Chen, Li, Jianhao, Tang, Yukuan, Wei, Minyan, Zhang, Lingmin, Su, Jianfen
• Format: Article
• Language: English
• Subjects: Cytokine storm; Liver clearance; Magnetic nanoparticles; Nanorobots; Neutrophils
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2023.113731

Cytokine storms characterized by excessive secretion of circulating cytokines and immune-cell hyperactivation are life-threatening systemic inflammatory syndromes. The new strategy is in great demand to inhibit the cytokine storm. Here, we designed a type of magnetically controlled nanorobots (MAGICIAN) by fusing neutrophil membranes onto Fe3O4 nanoparticles (Fe3O4NPs). In our study, the receptors of neutrophil membranes were successfully coated to the surface of Fe3O4NPs. The associated membrane functions of neutrophils were highly preserved. MAGICIAN could in vitro neutralize the inflammatory cytokines including interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ). Interestingly, MAGICIAN could be navigated to the liver sites under magnetic control and accelerated the cytokine clearance by the liver. Administration of MAGICIAN could efficiently relieve the inflammation in the acute lung injury mouse model. In addition, MAGICIAN displayed good biosafety in systemic administration. The present study provides a safe and convenient approach for the clearance of cytokine storms, indicating the potential for clinical application in acute lung injury therapy. [Display omitted] •MAGICIAN enable to bind with the pro-inflammatory cytokines.•MAGICIAN navigated effective cytokine clearance in the liver with magnetic field.•MAGICIAN showed improved stability in the presence or absence of serum.•MAGICIAN provided great potential for the personalized treatment.•MAGICIAN exhibited excellent biosafety.