Gastrointestinal Behçet's disease: Manifestations, diagnosis, and management

Behçet's disease (BD) is a rare, inflammatory vascular disorder with recurrent oral and genital aphthous ulcers, along with ocular and cutaneous manifestations. Gastrointestinal (GI) BD may involve any portion of the GI tract. However, it is commonly described in the terminal ileum, followed by...

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Bibliographic Details
Published in:Disease-a-month 2024-01, Vol.70 (1), p.101674-101674, Article 101674
Main Authors: Manuelyan, Zara, Butt, Edward, Parupudi, Sreeram
Format: Article
Language:English
Subjects:
Behçet's disease
disease activity index for intestinal Behçet's disease
Intestinal Behçet's
Therapeutic regimen
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Description
Summary:Behçet's disease (BD) is a rare, inflammatory vascular disorder with recurrent oral and genital aphthous ulcers, along with ocular and cutaneous manifestations. Gastrointestinal (GI) BD may involve any portion of the GI tract. However, it is commonly described in the terminal ileum, followed by the ileocecal region. Diagnosis is challenging given lack of pathognomonic tests; therefore, it is based on clinical criteria. Management of intestinal BD includes different classes of medications including corticosteroids, 5-aminosalicylic acid, immunomodulators, and anti-tumor necrosis factor alpha monoclonal antibody agents. In this review, we aim to focus on intestinal BD and provide details of clinical manifestations, diagnosis and therapeutic options of intestinal BD from gastroenterology viewpoint.
ISSN:0011-5029
1557-8194
DOI:10.1016/j.disamonth.2023.101674