Prognostic Impact of Preoperative Thrombocytosis on Recurrence-Free Survival in Patients with Upper Tract Urothelial Carcinoma

Background The aim of this work was to evaluate the prognostic potential of preoperative thrombocytosis for recurrence-free survival (RFS) and cancer-specific survival (CSS) among patients subjected to radical nephroureterectomy (RNU) due to UTUC. Patients and Methods Analytical cohort was composed...

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Published in:Annals of surgical oncology 2024-04, Vol.31 (4), p.2538-2544
Main Authors: Milojevic, Bogomir, Janicic, Aleksandar, Grozdic Milojevic, Isidora, Grubor, Nikola, Bumbasirevic, Uros, Radovanovic, Milan, Radisavcevic, Djordje, Jovanovic, Darko, Sretenovic, Milan, Durutovic, Otas, Sipetic Grujicic, Sandra
Format: Article
Language:English
Subjects:
Lymph nodes
Lymphatic system
Medicine
Medicine & Public Health
Metastases
Multivariate analysis
Oncology
Platelets
Regression analysis
Surgery
Surgical Oncology
Survival
Thrombocytosis
Tumors
Urologic Oncology
Urological cancer
Urothelial carcinoma
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Summary:Background The aim of this work was to evaluate the prognostic potential of preoperative thrombocytosis for recurrence-free survival (RFS) and cancer-specific survival (CSS) among patients subjected to radical nephroureterectomy (RNU) due to UTUC. Patients and Methods Analytical cohort was composed of a single-center series of 405 patients treated between January 1999 and December 2020. Thrombocytosis was defined as a platelet count exceeding the threshold value of 400 × 10 9 per L. Along with the Kaplan–Meier survival probability, Cox proportional hazard regression models were used. Results Preoperative thrombocytosis confirmed in 71 patients (17.5%) was significantly associated with the higher pathological tumor stage, lymph node metastasis, prior bladder cancer diagnosis, and preoperative anemia. With a median post-surgical follow-up period of 33.5 months, 125 patients (30.9%) experienced disease recurrence. The recurrence rate among patients with normal platelet levels was 13.6%, compared with 22.2% in those with preoperative thrombocytosis ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-023-14844-y