Contact Inhibition of Proliferation Is Accompanied by Expression of the PHF10D Subunit of the Chromatin Remodeling Complex PBAF in Mouse and Human Cell Lines

PHF10 is a subunit of the PBAF complex, which regulates the expression of many genes in developing and maturing organisms. PHF10 has four isoforms that differ in domain structure. The PHF10A isoform, containing a DPF domain at the C-terminus and 46 amino acids at the N-terminus, is necessary for the...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2023-12, Vol.513 (Suppl 1), p.S18-S22
Main Authors: Simonov, Yu. P., Tatarskiy, V. V., Georgieva, S. G., Soshnikova, N. V.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
C-Terminus
Cell Line
Cell lines
Cell Proliferation
Chromatin Assembly and Disassembly
Chromatin remodeling
Chromosomal Proteins, Non-Histone - metabolism
Contact Inhibition
Homeodomain Proteins - metabolism
Humans
Isoforms
Life Sciences
N-Terminus
Neoplasm Proteins
Protein Isoforms - metabolism
Transcription Factors - metabolism
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Summary:PHF10 is a subunit of the PBAF complex, which regulates the expression of many genes in developing and maturing organisms. PHF10 has four isoforms that differ in domain structure. The PHF10A isoform, containing a DPF domain at the C-terminus and 46 amino acids at the N-terminus, is necessary for the expression of proliferation genes; the functions of the other isoforms are less studied. In this work, we have established that, upon contact inhibition of mouse and human cell proliferation caused by the establishment of a tight junction and adherence junction between cells, the expression of the PHF10A isoform stops and instead the PHF10D isoform is expressed, which does not contain DPF-domain and N-terminal sequence. The function of the PHF10D isoform may be associated with the establishment of intercellular contacts.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672923700667