N6-(5-Phenylpentan-1-yl)adenine—A New Non-competitive Receptor-Specific Anti-cytokinin

For the first time, N 6 -(5-phenylpentan-1-yl)adenine, a synthetic adenine derivative with a receptor-specific anticytokinin effect, was obtained. This compound exhibits a pronounced anticytokinin effect, reducing cytokinin-induced expression of the GUS reporter gene when interacting with the cytoki...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2023-12, Vol.513 (Suppl 1), p.S23-S25
Main Authors: Zenchenko, A. A., Savelieva, E. M., Drenichev, M. S., Romanov, G. A., Oslovsky, V. E.
Format: Article
Language:English
Subjects:
Adenine
Arabidopsis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Cytokinins
Growth regulators
GUS gene
Life Sciences
Reporter gene
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Summary:For the first time, N 6 -(5-phenylpentan-1-yl)adenine, a synthetic adenine derivative with a receptor-specific anticytokinin effect, was obtained. This compound exhibits a pronounced anticytokinin effect, reducing cytokinin-induced expression of the GUS reporter gene when interacting with the cytokinin receptor CRE1/AHK4 of the model plant Arabidopsis thaliana . This effect manifests itself much weaker with the related AHK2 receptor and is not observed at all with the AHK3 receptor. We showed that N 6 -(5-phenylpentan-1-yl)adenine does not bind to the ligand-binding sites of the Arabidopsis cytokinin receptors, which does not allow it to be classified as a true cytokinin antagonist. Despite the currently unknown mechanism of action, this compound may find its use as a component of plant growth regulators. Like true anticytokinins, it enhances root growth of Arabidopsis seedlings, apparently suppressing the action of endogenous cytokinins on the “root” receptor CRE1/AHK4.
ISSN:1607-6729
1608-3091
DOI:10.1134/S1607672923700679