Prognostic value of right ventricular trabecular complexity in patients with arrhythmogenic cardiomyopathy

Objectives The present study aimed to investigate the incremental prognostic value of the right ventricular fractal dimension (FD), a novel marker of myocardial trabecular complexity by cardiac magnetic resonance (CMR) in patients with arrhythmogenic cardiomyopathy (ACM). Methods Consecutive patient...

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Bibliographic Details
Published in:European radiology 2024-08, Vol.34 (8), p.4883-4896
Main Authors: Chen, Bing-Hua, Jiang, Wen-Yi, Zheng, Jin-Yu, Dai, Yi-Si, Shi, Ruo-Yang, Wu, Rui, An, Dong-Aolei, Tang, Lang-Lang, Xu, Jian-Rong, Zhao, Lei, Wu, Lian-Ming
Format: Article
Language:English
Subjects:
Adult
Arrhythmogenic Right Ventricular Dysplasia - complications
Arrhythmogenic Right Ventricular Dysplasia - diagnostic imaging
Arrhythmogenic Right Ventricular Dysplasia - physiopathology
Cardiac
Cardiomyopathy
Cardiovascular diseases
Complexity
Death, Sudden, Cardiac
Diagnostic Radiology
Female
Fractal geometry
Fractals
Goodness of fit
Heart
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging, Cine - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Prognosis
Prospective Studies
Radiology
Reclassification
Regression analysis
Regression models
Risk factors
Statistical analysis
Statistical tests
Ultrasound
Ventricle
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Summary:Objectives The present study aimed to investigate the incremental prognostic value of the right ventricular fractal dimension (FD), a novel marker of myocardial trabecular complexity by cardiac magnetic resonance (CMR) in patients with arrhythmogenic cardiomyopathy (ACM). Methods Consecutive patients with ACM undergoing CMR were followed up for major cardiac events, including sudden cardiac death, aborted cardiac arrest, and appropriate implantable cardioverter defibrillator intervention. Prognosis prediction was compared by Cox regression analysis. We established a multivariable model supplemented with RV FD and evaluated its discrimination by Harrell’s C -statistic. We compared the category-free, continuous net reclassification improvement (cNRI) and integrated discrimination index (IDI) before and after the addition of FD. Results A total of 105 patients were prospectively included from three centers and followed up for a median of 60 (48, 66) months; experienced 36 major cardiac events were recorded. Trabecular FD displayed a strong unadjusted association with major cardiac events ( p  
ISSN:1432-1084
0938-7994
1432-1084
DOI:10.1007/s00330-023-10561-y