The role of microRNAs in brain metastasis

Brain metastasis (BM) is the most common type of brain tumor and frequently foreshadows disease progression and poor overall survival with patients having a median survival of 6 months. 70,000 new cases of BM are diagnosed each year in the United States (US) and the incidence rate for BM is increasi...

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Bibliographic Details
Published in:Journal of neuro-oncology 2024, Vol.166 (2), p.231-241
Main Authors: Hudson, Kadie, Mondia, Mark Willy, Zhang, Ying, Saha, Shekhar, Gibert, Myron K., Dube, Collin, Sun, Yunan, Marcinkiewicz, Pawel, Fadul, Camilo, Abounader, Roger
Format: Article
Language:English
Subjects:
Biomarkers
Brain cancer
Brain tumors
Gene expression
Medicine
Medicine & Public Health
Metastases
miRNA
Neurology
Non-coding RNA
Oncology
Review
Survival
Therapeutic targets
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Summary:Brain metastasis (BM) is the most common type of brain tumor and frequently foreshadows disease progression and poor overall survival with patients having a median survival of 6 months. 70,000 new cases of BM are diagnosed each year in the United States (US) and the incidence rate for BM is increasing with improved detection. MicroRNAs (miRNAs) are small non-coding RNAs that serve as critical regulators of gene expression and can act as powerful oncogenes and tumor suppressors. MiRNAs have been heavily implicated in cancer and proposed as biomarkers or therapeutic targets or agents. In this review, we summarize an extensive body of scientific work investigating the role of microRNAs in BM. We discuss miRNA dysregulation, functions, targets, and mechanisms of action in BM and present the current standing of miRNAs as biomarkers and potential therapeutics for BM. We conclude with future directions of miRNA basic and clinical research in BM.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-023-04541-x