Hemorrhagic Activity of Cationic Starch Conjugates with Sterically Hindered Phenol after Intravenous Administration to Guinea Pigs

Intravenous injection of cationic starch conjugated with sterically hindered phenol (terpenophenol) to guinea pigs did not increase hemorrhagic activity (in doses of 2 and 4 mg/kg) and plasma clotting time in activated partial thromboplastin time and prothrombin time tests (in a dose of 4 mg/kg) in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-12, Vol.176 (2), p.227-231
Main Authors: Drozd, N. N., Kuleshova, S. B., Torlopov, M. A., Udoratina, E. V.
Format: Article
Language:English
Subjects:
Biodistribution
Biomedical and Life Sciences
Biomedicine
Biotechnology
Blood
Cell Biology
Cellulose
Clotting
Drug delivery systems
Drug dosages
Hematology
Hemorrhage
Hydrogels
Internal Medicine
Intravenous administration
Laboratory animals
Laboratory Medicine
Medical examination
Medical research
Pathology
Phenols
Physiology
Plasma
Polymers
Prothrombin
Research centers
Science
Skin
Sodium
Starch
Thrombin
Thromboplastin
Thrombosis
Ventilation
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Summary:Intravenous injection of cationic starch conjugated with sterically hindered phenol (terpenophenol) to guinea pigs did not increase hemorrhagic activity (in doses of 2 and 4 mg/kg) and plasma clotting time in activated partial thromboplastin time and prothrombin time tests (in a dose of 4 mg/kg) in comparison with administration of physiological saline. Intravenous injection of the cationic starch conjugate with the highest content of terpenophenol fragments (4.1%wt) in a dose of 2 mg/kg to guinea pigs leads to a decrease in hemorrhagic activity by 4 times in comparison with the control.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-024-06000-7