Dosimetric and radiobiological comparison of IMRT, VMAT, and helical tomotherapy planning techniques in hippocampal sparing whole brain radiotherapy with simultaneous integrated boost for multiple brain metastases

• Published in: Radiation and environmental biophysics 2024-03, Vol.63 (1), p.47-57
• Main Authors: Balasubramanian, S., Shobana, M. K., Anabalagan, D., Thanasekar, P., Joel, S., Chaudhary, Prekshi
• Format: Article
• Language: English
• Subjects: Biological and Medical Physics; Biophysics; Brain; Brain cancer; Brain Neoplasms - radiotherapy; Brain Neoplasms - secondary; Dosimetry; Ecosystems; Effects of Radiation/Radiation Protection; Environmental Physics; Hippocampus; Homogeneity; Humans; Metastases; Metastasis; Monitoring/Environmental Analysis; Organs at Risk; Physics; Physics and Astronomy; Planning; Radiation therapy; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Retrospective Studies; TCP (protocol)
• ISSN: 0301-634X; 1432-2099; 1432-2099
• DOI: 10.1007/s00411-023-01052-1

To compare treatment planning and dosimetric outcomes for hippocampal sparing whole brain radiotherapy (WBRT) with the simultaneous integrated boost (SIB) in brain metastasis (BM) patients using tumour control probability (TCP) and normal tissue complication probability (NTCP) formalism between IMRT, VMAT, and HT techniques. In this retrospective study, the treatment data of 20 BM patients who typically received whole brain radiation with SIB treatment were used. Prescription doses of 30 Gy and 36 Gy was delivered in 10 fractions for WBRT and SIB, respectively. Niemierko and LKB models were applied for calculating TCP and NTCP. All the plans were evaluated for the RTOG 0933 protocol criteria and found acceptable. Additionally, the homogeneity of the PTV boost is 0.07 ± 0.01, 0.1 ± 0.04, and 0.08 ± 0.02 for IMRT, VMAT, and HT, respectively ( P