The rise of precision cellular therapies

Advances in gene, protein and cellular engineering provide unprecedented opportunities to redirect immune cells to treat autoimmunity. In 2023, novel cellular and precision immunotherapies showed remarkable promise in the treatment of rheumatic diseases. Key advances B cell-targeted CAR T cell thera...

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Bibliographic Details
Published in:Nature reviews. Rheumatology 2024-02, Vol.20 (2), p.69-70
Main Author: Konig, Maximilian F.
Format: Article
Language:English
Subjects:
692/4023
692/700/565
Antibodies
Antigens
Arthritis
Autoimmune diseases
Autoimmunity
Cell therapy
Cloning
Cytokines
Humans
Immunotherapy
Infections
Kinases
Lupus
Lymphocytes
Lymphocytes T
Medical research
Medicine
Medicine & Public Health
Molecular Targeted Therapy
Myasthenia gravis
Patients
Precision Medicine
Protein engineering
Remission
Remission (Medicine)
Rheumatic diseases
Rheumatology
T cell receptors
Year in Review
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Summary:Advances in gene, protein and cellular engineering provide unprecedented opportunities to redirect immune cells to treat autoimmunity. In 2023, novel cellular and precision immunotherapies showed remarkable promise in the treatment of rheumatic diseases. Key advances B cell-targeted CAR T cell therapies can achieve prolonged clinical remission in various autoimmune diseases 2 , 5 . Precision cellular therapies hold promise for selective, antigen-specific elimination of autoreactive B cells 6 . TCR β-chain variable (TRBV)-targeted antibodies also show potential in T cell-mediated rheumatic diseases 10 .
ISSN:1759-4790
1759-4804
DOI:10.1038/s41584-023-01073-6