Clinical outcomes and complications of S53P4 bioactive glass in chronic osteomyelitis and septic non-unions: a retrospective single-center study

Introduction Dead space management following debridement surgery in chronic osteomyelitis or septic non-unions is one of the most crucial and discussed steps for the success of the surgical treatment of these conditions. In this retrospective clinical study, we described the efficacy and safety prof...

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Published in:European journal of clinical microbiology & infectious diseases 2024-03, Vol.43 (3), p.489-499
Main Authors: Gatti, Simone Daniel, Gaddi, Diego, Turati, Marco, Leone, Giulio, Arts, Jacobus J., Pessina, Fabio, Carminati, Mattia, Zatti, Giovanni, De Rosa, Laura, Bigoni, Marco
Format: Article
Language:English
Subjects:
Bioglass
Biological activity
Biomedical and Life Sciences
Biomedicine
Bone healing
Debridement
Dehiscence
Healing
Internal Medicine
Medical Microbiology
Nonunion
Original Article
Osteomyelitis
Patients
Unions
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Summary:Introduction Dead space management following debridement surgery in chronic osteomyelitis or septic non-unions is one of the most crucial and discussed steps for the success of the surgical treatment of these conditions. In this retrospective clinical study, we described the efficacy and safety profile of surgical debridement and local application of S53P4 bioactive glass (S53P4 BAG) in the treatment of bone infections. Methods A consecutive single-center series of 38 patients with chronic osteomyelitis (24) and septic non-unions (14), treated with bioactive glass S53P4 as dead space management following surgical debridement between May 2015 and November 2020, were identified and evaluated retrospectively. Results Infection eradication was reached in 22 out of 24 patients (91.7%) with chronic osteomyelitis. Eleven out of 14 patients (78.6%) with septic non-union achieved both fracture healing and infection healing in 9.1 ± 4.9 months. Three patients (7.9%) developed prolonged serous discharge with wound dehiscence but healed within 2 months with no further surgical intervention. Average patient follow-up time was 19.8 months ± 7.6 months. Conclusion S53P4 bioactive glass is an effective and safe therapeutic option in the treatment of chronic osteomyelitis and septic non-unions because of its unique antibacterial properties, but also for its ability to generate a growth response in the remaining healthy bone at the bone-glass interface.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-023-04737-z