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Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns
Objective Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns. Study design Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from...
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| Published in: | Journal of perinatology 2024-04, Vol.44 (4), p.554-560 |
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| container_end_page | 560 |
| container_issue | 4 |
| container_start_page | 554 |
| container_title | Journal of perinatology |
| container_volume | 44 |
| creator | Valentine, Gregory C. Perez, Krystle M. Wood, Thomas R. Mayock, Dennis E. Law, Janessa B. Kolnik, Sarah Strobel, Katie M. Brandon, Olivia C. Comstock, Bryan A. Heagerty, Patrick J. Juul, Sandra E. |
| description | Objective
Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study design
Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
Results
Among
n
= 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: −5.0 points, [CI −9.5, −0.6]) and lower motor scores (≤1 day versus ≥8 days: −4.6 points [CI −9.2, −0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤−50 percent-days: −5.6, [CI −9.4, −1.8]), motor scores (≤−50 percent-days: −4.2, [CI -8.2, -0.2]); and language scores (≤−50 percent-days: −6.0, [CI −10.1, −1.9]).
Conclusion
Faster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes.
Trial registration
PENUT Trial Registration: NCT01378273.
https://clinicaltrials.gov/ct2/show/NCT01378273
.
Clinical trial registration
This study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273). |
| doi_str_mv | 10.1038/s41372-024-01869-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2913081415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2913081415</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-e78320c2e937df88584c8ca2f2b886946acb023fc80adb3318ba345b6734b3093</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhS0EotPHH2CBLLFhE7B9ncRZoqo8pEps2rVlOzczrhJ7sB2m_fe4nQISC1Z3cb9z7uMQ8oazD5yB-pglh140TMiGcdUNjXpBNlz2XdO2El6SDeslNApkd0JOc75j7LHZvyYnoPjQDkJsyHzjF6Ql0oRb4wO1PpXdAf12V6gJIzU5R-dN8THQgy87GnBNccSfOMf9gqGYmca1uLhgpmaJYUvxviRccH6g-4QF01I1BxtTyOfk1WTmjBfP9Yzcfr66ufzaXH__8u3y03XjJB9Kg70CwZzAAfpxUqpV0ilnxCSsqmfKzjjLBExOMTNaAK6sAdnargdpgQ1wRt4fffcp_lgxF7347HCeTcC4Zi0GDkxxyduKvvsHvYtrCnU7DQykksDbvlLiSLkUc0446X3yi0kPmjP9mIU-ZqFrFvopC62q6O2z9WoXHP9Ifj-_AnAEcm2FLaa_s_9j-wvqG5Yi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3034843157</pqid></control><display><type>article</type><title>Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns</title><source>Nexis UK</source><source>Springer Nature</source><creator>Valentine, Gregory C. ; Perez, Krystle M. ; Wood, Thomas R. ; Mayock, Dennis E. ; Law, Janessa B. ; Kolnik, Sarah ; Strobel, Katie M. ; Brandon, Olivia C. ; Comstock, Bryan A. ; Heagerty, Patrick J. ; Juul, Sandra E.</creator><creatorcontrib>Valentine, Gregory C. ; Perez, Krystle M. ; Wood, Thomas R. ; Mayock, Dennis E. ; Law, Janessa B. ; Kolnik, Sarah ; Strobel, Katie M. ; Brandon, Olivia C. ; Comstock, Bryan A. ; Heagerty, Patrick J. ; Juul, Sandra E.</creatorcontrib><description>Objective
Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study design
Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
Results
Among
n
= 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: −5.0 points, [CI −9.5, −0.6]) and lower motor scores (≤1 day versus ≥8 days: −4.6 points [CI −9.2, −0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤−50 percent-days: −5.6, [CI −9.4, −1.8]), motor scores (≤−50 percent-days: −4.2, [CI -8.2, -0.2]); and language scores (≤−50 percent-days: −6.0, [CI −10.1, −1.9]).
Conclusion
Faster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes.
Trial registration
PENUT Trial Registration: NCT01378273.
https://clinicaltrials.gov/ct2/show/NCT01378273
.
Clinical trial registration
This study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273).</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-024-01869-8</identifier><identifier>PMID: 38195922</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/443/319 ; 692/499 ; 692/700/1720 ; Birth Weight ; Child ; Child development ; Cognitive ability ; Developmental Disabilities - epidemiology ; Developmental Disabilities - etiology ; Erythropoietin ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn ; Medicine ; Medicine & Public Health ; Neonates ; Neurodevelopment ; Neurodevelopmental disorders ; Neuroprotection ; Pediatric Surgery ; Pediatrics ; Premature babies ; Premature birth ; Registration ; Secondary analysis ; Weight Loss</subject><ispartof>Journal of perinatology, 2024-04, Vol.44 (4), p.554-560</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-e78320c2e937df88584c8ca2f2b886946acb023fc80adb3318ba345b6734b3093</citedby><cites>FETCH-LOGICAL-c419t-e78320c2e937df88584c8ca2f2b886946acb023fc80adb3318ba345b6734b3093</cites><orcidid>0000-0002-1130-2720 ; 0000-0003-1397-8430 ; 0000-0002-6861-6229 ; 0000-0002-6190-4842 ; 0000-0002-7717-0425 ; 0000-0002-3055-2987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38195922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valentine, Gregory C.</creatorcontrib><creatorcontrib>Perez, Krystle M.</creatorcontrib><creatorcontrib>Wood, Thomas R.</creatorcontrib><creatorcontrib>Mayock, Dennis E.</creatorcontrib><creatorcontrib>Law, Janessa B.</creatorcontrib><creatorcontrib>Kolnik, Sarah</creatorcontrib><creatorcontrib>Strobel, Katie M.</creatorcontrib><creatorcontrib>Brandon, Olivia C.</creatorcontrib><creatorcontrib>Comstock, Bryan A.</creatorcontrib><creatorcontrib>Heagerty, Patrick J.</creatorcontrib><creatorcontrib>Juul, Sandra E.</creatorcontrib><title>Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study design
Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
Results
Among
n
= 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: −5.0 points, [CI −9.5, −0.6]) and lower motor scores (≤1 day versus ≥8 days: −4.6 points [CI −9.2, −0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤−50 percent-days: −5.6, [CI −9.4, −1.8]), motor scores (≤−50 percent-days: −4.2, [CI -8.2, -0.2]); and language scores (≤−50 percent-days: −6.0, [CI −10.1, −1.9]).
Conclusion
Faster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes.
Trial registration
PENUT Trial Registration: NCT01378273.
https://clinicaltrials.gov/ct2/show/NCT01378273
.
Clinical trial registration
This study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273).</description><subject>631/443/319</subject><subject>692/499</subject><subject>692/700/1720</subject><subject>Birth Weight</subject><subject>Child</subject><subject>Child development</subject><subject>Cognitive ability</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Developmental Disabilities - etiology</subject><subject>Erythropoietin</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Extremely Premature</subject><subject>Infant, Newborn</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Neurodevelopment</subject><subject>Neurodevelopmental disorders</subject><subject>Neuroprotection</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Premature babies</subject><subject>Premature birth</subject><subject>Registration</subject><subject>Secondary analysis</subject><subject>Weight Loss</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1DAUhS0EotPHH2CBLLFhE7B9ncRZoqo8pEps2rVlOzczrhJ7sB2m_fe4nQISC1Z3cb9z7uMQ8oazD5yB-pglh140TMiGcdUNjXpBNlz2XdO2El6SDeslNApkd0JOc75j7LHZvyYnoPjQDkJsyHzjF6Ql0oRb4wO1PpXdAf12V6gJIzU5R-dN8THQgy87GnBNccSfOMf9gqGYmca1uLhgpmaJYUvxviRccH6g-4QF01I1BxtTyOfk1WTmjBfP9Yzcfr66ufzaXH__8u3y03XjJB9Kg70CwZzAAfpxUqpV0ilnxCSsqmfKzjjLBExOMTNaAK6sAdnargdpgQ1wRt4fffcp_lgxF7347HCeTcC4Zi0GDkxxyduKvvsHvYtrCnU7DQykksDbvlLiSLkUc0446X3yi0kPmjP9mIU-ZqFrFvopC62q6O2z9WoXHP9Ifj-_AnAEcm2FLaa_s_9j-wvqG5Yi</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Valentine, Gregory C.</creator><creator>Perez, Krystle M.</creator><creator>Wood, Thomas R.</creator><creator>Mayock, Dennis E.</creator><creator>Law, Janessa B.</creator><creator>Kolnik, Sarah</creator><creator>Strobel, Katie M.</creator><creator>Brandon, Olivia C.</creator><creator>Comstock, Bryan A.</creator><creator>Heagerty, Patrick J.</creator><creator>Juul, Sandra E.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1130-2720</orcidid><orcidid>https://orcid.org/0000-0003-1397-8430</orcidid><orcidid>https://orcid.org/0000-0002-6861-6229</orcidid><orcidid>https://orcid.org/0000-0002-6190-4842</orcidid><orcidid>https://orcid.org/0000-0002-7717-0425</orcidid><orcidid>https://orcid.org/0000-0002-3055-2987</orcidid></search><sort><creationdate>20240401</creationdate><title>Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns</title><author>Valentine, Gregory C. ; Perez, Krystle M. ; Wood, Thomas R. ; Mayock, Dennis E. ; Law, Janessa B. ; Kolnik, Sarah ; Strobel, Katie M. ; Brandon, Olivia C. ; Comstock, Bryan A. ; Heagerty, Patrick J. ; Juul, Sandra E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-e78320c2e937df88584c8ca2f2b886946acb023fc80adb3318ba345b6734b3093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>631/443/319</topic><topic>692/499</topic><topic>692/700/1720</topic><topic>Birth Weight</topic><topic>Child</topic><topic>Child development</topic><topic>Cognitive ability</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Developmental Disabilities - etiology</topic><topic>Erythropoietin</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Extremely Premature</topic><topic>Infant, Newborn</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Neurodevelopment</topic><topic>Neurodevelopmental disorders</topic><topic>Neuroprotection</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Premature babies</topic><topic>Premature birth</topic><topic>Registration</topic><topic>Secondary analysis</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valentine, Gregory C.</creatorcontrib><creatorcontrib>Perez, Krystle M.</creatorcontrib><creatorcontrib>Wood, Thomas R.</creatorcontrib><creatorcontrib>Mayock, Dennis E.</creatorcontrib><creatorcontrib>Law, Janessa B.</creatorcontrib><creatorcontrib>Kolnik, Sarah</creatorcontrib><creatorcontrib>Strobel, Katie M.</creatorcontrib><creatorcontrib>Brandon, Olivia C.</creatorcontrib><creatorcontrib>Comstock, Bryan A.</creatorcontrib><creatorcontrib>Heagerty, Patrick J.</creatorcontrib><creatorcontrib>Juul, Sandra E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valentine, Gregory C.</au><au>Perez, Krystle M.</au><au>Wood, Thomas R.</au><au>Mayock, Dennis E.</au><au>Law, Janessa B.</au><au>Kolnik, Sarah</au><au>Strobel, Katie M.</au><au>Brandon, Olivia C.</au><au>Comstock, Bryan A.</au><au>Heagerty, Patrick J.</au><au>Juul, Sandra E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>44</volume><issue>4</issue><spage>554</spage><epage>560</epage><pages>554-560</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective
Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study design
Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to regain birthweight, time from birth to weight nadir, time from nadir to regain birthweight, and cumulative weight loss with 2-year corrected Bayley Scales of Infant and Toddler Development 3rd edition.
Results
Among
n
= 654 EP neonates, those with shorter nadir-to-regain had lower cognitive scores (≤1 day versus ≥8 days: −5.0 points, [CI −9.5, −0.6]) and lower motor scores (≤1 day versus ≥8 days: −4.6 points [CI −9.2, −0.03]) in adjusted stepwise forward regression modeling. Increasingly cumulative weight loss was associated with lower cognitive scores (≤−50 percent-days: −5.6, [CI −9.4, −1.8]), motor scores (≤−50 percent-days: −4.2, [CI -8.2, -0.2]); and language scores (≤−50 percent-days: −6.0, [CI −10.1, −1.9]).
Conclusion
Faster nadir-to-regain and excessive cumulative weight loss are associated with adverse 2-year neurodevelopmental outcomes.
Trial registration
PENUT Trial Registration: NCT01378273.
https://clinicaltrials.gov/ct2/show/NCT01378273
.
Clinical trial registration
This study is a post-hoc secondary analysis of pre-existing data from the PENUT Trial (NCT #01378273).</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38195922</pmid><doi>10.1038/s41372-024-01869-8</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1130-2720</orcidid><orcidid>https://orcid.org/0000-0003-1397-8430</orcidid><orcidid>https://orcid.org/0000-0002-6861-6229</orcidid><orcidid>https://orcid.org/0000-0002-6190-4842</orcidid><orcidid>https://orcid.org/0000-0002-7717-0425</orcidid><orcidid>https://orcid.org/0000-0002-3055-2987</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2024-04, Vol.44 (4), p.554-560 |
| issn | 0743-8346 1476-5543 |
| language | eng |
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| source | Nexis UK; Springer Nature |
| subjects | 631/443/319 692/499 692/700/1720 Birth Weight Child Child development Cognitive ability Developmental Disabilities - epidemiology Developmental Disabilities - etiology Erythropoietin Humans Infant Infant, Extremely Premature Infant, Newborn Medicine Medicine & Public Health Neonates Neurodevelopment Neurodevelopmental disorders Neuroprotection Pediatric Surgery Pediatrics Premature babies Premature birth Registration Secondary analysis Weight Loss |
| title | Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns |
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