Unlocking translational machinery for antitubercular drug development

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) 2024-03, Vol.49 (3), p.195-198
• Main Authors: Kumar, Navneet, Wani, Mushtaq Ahmad, Raje, Chaaya Iyengar, Garg, Prabha
• Format: Article
• Language: English
• Subjects: elongation factor G (EF-G); elongation factor thermo stable (EF-Ts); elongation factor thermo unstable (EF-Tu); Mycobacterium tuberculosis; structure-based drug design (SBDD); translational factor proteins
• ISSN: 0968-0004; 1362-4326
• DOI: 10.1016/j.tibs.2023.12.008

Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable–GDP (EF-Tu–GDP), elongation factor thermo stable–EF-Tu (EF-Ts–EF-Tu), and elongation factor G–GDP (EF-G–GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies. Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable–GDP (EF-Tu–GDP), elongation factor thermo stable–EF-Tu (EF-Ts–EF-Tu), and elongation factor G–GDP (EF-G–GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies.