Prediction of preterm birth in growth‐restricted and appropriate‐for‐gestational‐age infants using maternal PlGF and the sFlt‐1/PlGF ratio—A prospective study

Objective To assess the utility of placental growth factor (PlGF) levels and the soluble fms‐like tyrosine kinase‐1/placental growth factor (sFlt‐1/PlGF) ratio to predict preterm birth (PTB) for infants with fetal growth restriction (FGR) and those appropriate for gestational age (AGA). Design Prosp...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2024-07, Vol.131 (8), p.1089-1101
Main Authors: Hong, Jesrine, Crawford, Kylie, Cavanagh, Erika, Silva Costa, Fabricio, Kumar, Sailesh
Format: Article
Language:English
Subjects:
Birth
fetal growth restriction
Fetuses
Gestational age
Growth factors
Infants
Placenta
Placenta growth factor
placental dysfunction
placental growth factor
Pregnancy
Premature birth
preterm birth
pre‐eclampsia
Risk assessment
sFlt‐1/PlGF ratio
small for gestational age
soluble fms‐like tyrosine kinase 1
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Summary:Objective To assess the utility of placental growth factor (PlGF) levels and the soluble fms‐like tyrosine kinase‐1/placental growth factor (sFlt‐1/PlGF) ratio to predict preterm birth (PTB) for infants with fetal growth restriction (FGR) and those appropriate for gestational age (AGA). Design Prospective, observational cohort study. Setting Tertiary maternity hospital in Australia. Population There were 320 singleton pregnancies: 141 (44.1%) AGA, 83 (25.9%) early FGR (
ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/1471-0528.17752