A combined finite-discrete element method for simulating pharmaceutical powder tableting

The pharmaceutical powder and tableting process is simulated using a combined finite‐discrete element method and contact dynamics for irregular‐shaped particles. The particle‐scale formulation and two‐stage contact detection algorithm which has been developed for the proposed method enhances the ove...

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Bibliographic Details
Published in:International journal for numerical methods in engineering 2005-02, Vol.62 (7), p.853-869
Main Authors: Lewis, Roland W., Gethin, David T., Yang, Xinshe S., Rowe, Ray C.
Format: Article
Language:English
Subjects:
discrete element method
elasticity
Exact sciences and technology
finite element analysis
Fundamental areas of phenomenology (including applications)
pharmaceutical powder
Physics
Solid mechanics
Static elasticity (thermoelasticity...)
Structural and continuum mechanics
tableting
viscoelasticity
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Summary:The pharmaceutical powder and tableting process is simulated using a combined finite‐discrete element method and contact dynamics for irregular‐shaped particles. The particle‐scale formulation and two‐stage contact detection algorithm which has been developed for the proposed method enhances the overall calculation efficiency for particle interaction characteristics. The irregular particle shapes and random sizes are represented as a pseudo‐particle assembly having a scaled up geometry but based on the variations of real powder particles. Our simulations show that particle size, shapes and material properties have a significant influence on the behaviour of compaction and deformation. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0029-5981
1097-0207
DOI:10.1002/nme.1287