Prospective study design and data analysis in UK Biobank

Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improv...

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Bibliographic Details
Published in:Science translational medicine 2024-01, Vol.16 (729), p.eadf4428-eadf4428
Main Authors: Allen, Naomi E, Lacey, Ben, Lawlor, Deborah A, Pell, Jill P, Gallacher, John, Smeeth, Liam, Elliott, Paul, Matthews, Paul M, Lyons, Ronan A, Whetton, Anthony D, Lucassen, Anneke, Hurles, Matthew E, Chapman, Michael, Roddam, Andrew W, Fitzpatrick, Natalie K, Hansell, Anna L, Hardy, Rebecca, Marioni, Riccardo E, O'Donnell, Valerie B, Williams, Julie, Lindgren, Cecilia M, Effingham, Mark, Sellors, Jonathan, Danesh, John, Collins, Rory
Format: Article
Language:English
Subjects:
Biological Specimen Banks
Data Analysis
Humans
Prospective Studies
Research Design
UK Biobank
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Summary:Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.
ISSN:1946-6234
1946-6242
DOI:10.1126/scitranslmed.adf4428