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Psiguanol, a novel α-pyrone derivative from Psidium guajava leaves and vasorelaxant activity in rat aorta cells through intracellular cGMP-dependent opening of calcium-activated potassium channels
The phytochemical investigation of leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol ( ), as new compound along with guaja...
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| Published in: | Natural product research 2024-01, p.1-14 |
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| Main Authors: | , , , , , , , |
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| Language: | English |
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| creator | Srivastava, Shraddha Mishra, Divya Bisht, Rohit Savita, Kumari Singh, Kishan Rani, Poonam Chanda, Debabrata Dev, Kapil |
| description | The phytochemical investigation of
leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol (
), as new compound along with guajadial (
), psidial A (
),
-caryophyllene (
), quercetin (
), avicularin (
), guaijaverin (
), hyperin (
), rutin (
), ursolic acid (
), corosolic acid (
), asiatic acid (
),
-sitosterol (
),
-sitosterol-D-glucoside (
), ellagic acid (
), 3,3',4'-trimethylellagic acid 4-O-glucoside (
), protocatechuic acid (
), gallic acid (
), and tricosanoic acid (
) as known molecules. The compound
was isolated for the first time from this plant. The isolated compounds were evaluated for vasorelaxation activity in rat aorta cells and it was observed that compound
exhibited the most potent vasorelaxation response in the
model in isolated rat aorta cells. Mechanistically, the vasorelaxation activity of
was mediated through cGMP-dependent BK
channel opening. |
| doi_str_mv | 10.1080/14786419.2023.2294477 |
| format | article |
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leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol (
), as new compound along with guajadial (
), psidial A (
),
-caryophyllene (
), quercetin (
), avicularin (
), guaijaverin (
), hyperin (
), rutin (
), ursolic acid (
), corosolic acid (
), asiatic acid (
),
-sitosterol (
),
-sitosterol-D-glucoside (
), ellagic acid (
), 3,3',4'-trimethylellagic acid 4-O-glucoside (
), protocatechuic acid (
), gallic acid (
), and tricosanoic acid (
) as known molecules. The compound
was isolated for the first time from this plant. The isolated compounds were evaluated for vasorelaxation activity in rat aorta cells and it was observed that compound
exhibited the most potent vasorelaxation response in the
model in isolated rat aorta cells. Mechanistically, the vasorelaxation activity of
was mediated through cGMP-dependent BK
channel opening.</description><identifier>ISSN: 1478-6419</identifier><identifier>EISSN: 1478-6427</identifier><identifier>DOI: 10.1080/14786419.2023.2294477</identifier><identifier>PMID: 38198584</identifier><language>eng</language><publisher>England</publisher><ispartof>Natural product research, 2024-01, p.1-14</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1024-75b45d3c220c3a7efaa670358599a863b6f1e871ddd9bc32997c8b7987333f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38198584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srivastava, Shraddha</creatorcontrib><creatorcontrib>Mishra, Divya</creatorcontrib><creatorcontrib>Bisht, Rohit</creatorcontrib><creatorcontrib>Savita, Kumari</creatorcontrib><creatorcontrib>Singh, Kishan</creatorcontrib><creatorcontrib>Rani, Poonam</creatorcontrib><creatorcontrib>Chanda, Debabrata</creatorcontrib><creatorcontrib>Dev, Kapil</creatorcontrib><title>Psiguanol, a novel α-pyrone derivative from Psidium guajava leaves and vasorelaxant activity in rat aorta cells through intracellular cGMP-dependent opening of calcium-activated potassium channels</title><title>Natural product research</title><addtitle>Nat Prod Res</addtitle><description>The phytochemical investigation of
leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol (
), as new compound along with guajadial (
), psidial A (
),
-caryophyllene (
), quercetin (
), avicularin (
), guaijaverin (
), hyperin (
), rutin (
), ursolic acid (
), corosolic acid (
), asiatic acid (
),
-sitosterol (
),
-sitosterol-D-glucoside (
), ellagic acid (
), 3,3',4'-trimethylellagic acid 4-O-glucoside (
), protocatechuic acid (
), gallic acid (
), and tricosanoic acid (
) as known molecules. The compound
was isolated for the first time from this plant. The isolated compounds were evaluated for vasorelaxation activity in rat aorta cells and it was observed that compound
exhibited the most potent vasorelaxation response in the
model in isolated rat aorta cells. Mechanistically, the vasorelaxation activity of
was mediated through cGMP-dependent BK
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leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol (
), as new compound along with guajadial (
), psidial A (
),
-caryophyllene (
), quercetin (
), avicularin (
), guaijaverin (
), hyperin (
), rutin (
), ursolic acid (
), corosolic acid (
), asiatic acid (
),
-sitosterol (
),
-sitosterol-D-glucoside (
), ellagic acid (
), 3,3',4'-trimethylellagic acid 4-O-glucoside (
), protocatechuic acid (
), gallic acid (
), and tricosanoic acid (
) as known molecules. The compound
was isolated for the first time from this plant. The isolated compounds were evaluated for vasorelaxation activity in rat aorta cells and it was observed that compound
exhibited the most potent vasorelaxation response in the
model in isolated rat aorta cells. Mechanistically, the vasorelaxation activity of
was mediated through cGMP-dependent BK
channel opening.</abstract><cop>England</cop><pmid>38198584</pmid><doi>10.1080/14786419.2023.2294477</doi><tpages>14</tpages></addata></record> |
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| source | Taylor and Francis Science and Technology Collection |
| title | Psiguanol, a novel α-pyrone derivative from Psidium guajava leaves and vasorelaxant activity in rat aorta cells through intracellular cGMP-dependent opening of calcium-activated potassium channels |
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