Antioxidative and anti-inflammatory activities of Erica spiculifolia extracts and fractions

There is little data on the phytochemical/pharmacological properties of Salisb. (syn. (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test...

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Published in:Natural product research 2024-01, p.1-10
Main Authors: Pavlović, Dragana R, Dobrić, Silva, Stojanović, Nikola, Zlatković, Bojan, Matejić, Jelena, Kovačević, Nada
Format: Article
Language:English
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Summary:There is little data on the phytochemical/pharmacological properties of Salisb. (syn. (Salisb.) Rchb.). This study examines the antioxidative and anti-inflammatory activities of different extracts and fractions of on isolated rat peritoneal macrophages, in the carrageenan-induced rat paw oedema test, BSA test, and two complementary antioxidant assays. Ethanolic extracts of leaves, flowers, and aboveground parts, and petroleum ether, ether, ethyl acetate, and water fractionations of the ethanol extract of applied at doses of 50-200 mg/kg exhibited dose-dependent anti-inflammatory activity comparable with indomethacin. All tested samples, except for the petroleum ether fraction, exerted excellent antioxidant activity, and all of them exhibited significant and similar inhibition of BSA denaturation comparable with diclofenac. Ethanolic extract of the aboveground parts obtained by percolation, ethyl acetate and water fractions had the highest efficiency, attenuating inflammation by more than 50% in the lowest applied concentration alongside exceptional radical scavenging activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2023.2301677