Associations between antipsychotics exposure and dementia risk: A prospective cohort study of 415,100 participants

Antipsychotics (APs) are among the most widely prescribed medications, and have been shown to cause cognitive decline. But previous studies on their effects on dementia risk are controversial and scarce. We aimed to examine the relationships of APs exposure with the risk of dementia. Data were obtai...

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Bibliographic Details
Published in:Journal of affective disorders 2024-03, Vol.349, p.201-209
Main Authors: Ma, Li-Yun, Ou, Ya-Nan, Gao, Pei-Yang, Fu, Yan, Zhang, Dan-Dan, Yang, Liu, Feng, Jian-Feng, Cheng, Wei, Tan, Lan, Yu, Jin-Tai
Format: Article
Language:English
Subjects:
Antipsychotic
Atypical antipsychotic
Dementia
Dose-response analyses
Typical antipsychotic
UK Biobank
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Summary:Antipsychotics (APs) are among the most widely prescribed medications, and have been shown to cause cognitive decline. But previous studies on their effects on dementia risk are controversial and scarce. We aimed to examine the relationships of APs exposure with the risk of dementia. Data were obtained from a prospective cohort of 415,100 UK Biobank (UKB) participants. We investigated the effects of APs exposure and their various classes on dementia risk by using multivariable Cox proportional hazard models and further the dose-response effects of oral APs. After a mean follow-up of 8.64 years, 5235 (1.3 %) participants developed all-cause dementia (ACD), among whom 2313 (0.6 %) developed Alzheimer's disease (AD), and 1213 (0.3 %) developed vascular dementia (VaD). Exposure to any APs conferred increased risks of ACD (HR: 1.33, 95 % CI = 1.17–1.51, P 
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2024.01.029