Vibrational spectroscopic detection and analysis of salicylic acid and aspirin binary cocrystal

• Published in: International journal of pharmaceutics 2024-02, Vol.651, p.123767-123767, Article 123767
• Main Authors: Peng, Bo, Shu, Jingyi, Hou, Zeyu, Qian, Siyu, Yan, Bingxin, Zhang, Boyan, Zhao, Yuhan, Su, Bo, Zhang, Cunlin
• Format: Article
• Language: English
• Subjects: Aspirin; Raman; Salicylic acid; THz-TDS; XRPD
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2024.123767

[Display omitted] Salicylic acid is a raw material for preparing aspirin and holds an important position in medical history. Studying the crystallization of these two drugs is of great significance in improving their dissolution rate, bioavailability, and physical stability. Although various techniques have been used for structural characterization, there is still a lack of information on the collective vibrational behavior of aspirin and salicylic acid eutectic compounds. Firstly, two starting materials (salicylic acid and aspirin) were ground in a 1:1 M ratio to prepare eutectic compounds. The eutectic composition was studied using vibrational spectroscopy techniques, such as X-ray powder diffusion (XRPD), terahertz time-domain spectroscopy (THz-TDS), and Raman spectroscopy. Additionally, the structure of the aspirin and salicylic acid eutectic was simulated and optimized using density functional theory. It was found that the eutectic type II was the most consistent with the experiment, and the corresponding vibration modes of each peak were provided. These results offer a unique method for characterizing the structural composition of eutectic crystals, which can be utilized to enhance the physical and chemical properties, as well as the pharmacological activity, of specific drugs at the molecular level.